High-Precision Mass Spectrometry Imaging Facility

高精度质谱成像设备

• 批准号: LE230100153
• 负责人: Prof Nicolas Voelcker
• 金额: $ 65.61万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Infrastructure, Equipment and Facilities
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-03-17 至 2023-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LE230100153
• 关键词: Precision; Mass; Spectrometry; Imaging; Facility

This proposal aims to build an advanced chemical mapping facility through the acquisition of high-resolution ion mobility mass spectrometry instrumentation capable of 2D/3D spatial analysis using laser desorption/ionisation, from centimetre (whole tissues) to micrometer (sub-cellular) scale. This facility will create a concentration of world leading expertise in spatial chemical phenotyping from diverse fields including nanofabrication, chemical engineering, systems-biology, drug discovery, environmental ecology, agricultural biosciences and diagnostic sciences. The facility will enable translational research by applying breakthroughs in chemical synthesis, nanofabrication, bioconjugation, proteomics and metabolomics to spatial systems.

该提案旨在通过获得能够使用激光解吸/电离进行2D/3D空间分析的高分辨率离子迁移质谱仪，建立一个先进的化学绘图设施，从厘米（整个组织）到微米（亚细胞）尺度。该设施将集中来自不同领域的世界领先的空间化学表型专业知识，包括纳米纤维，化学工程，系统生物学，药物发现，环境生态学，农业生物科学和诊断科学。该设施将通过将化学合成、纳米纤维、生物缀合、蛋白质组学和代谢组学的突破应用于空间系统来实现转化研究。