CRB: Conservation Genetics and Inbreeding Depression

濒危物种的保护往往取决于避免近亲繁殖抑制或保留遗传变异。因此，了解和描述近交抑制现象对保护生物学具有重要意义。在拟议的研究中，将黑腹果蝇的近亲繁殖抑制作为濒危物种的模型，在这种实验中是不可能的。近交对适合度各组成部分的影响将被检验。此外，为了更真实地了解近交对濒危物种的影响，还将对正常实验室环境和两种应激环境下近交的影响进行研究。在研究的第二个组成部分，将开发一个计算机模拟程序来分析系谱种群。遗传连锁和自然选择将结合起来。因此，不同近交率对近交抑制的影响和清除种群致命等位基因的条件将被确定。此外，该技术将应用于已知的濒危物种系谱，以确定预期的近交抑制。

The conservation of endangered species often hinges on the avoidance of inbreeding depression or the retention of genetic variation. Therefore, it is of fundamental importance for conservation biology to understand and characterize inbreeding depression. In the proposed research, inbreeding depression in Drosophila melanogaster as a model for endangered species in which such experimentation would not be possible. The influence of inbreeding on all components of fitness will be examined. In addition, the effect of inbreeding in the normal laboratory environment and two stress environments will be examined to obtain a more realistic view of the impact of inbreeding on endangered species. In a second component of the study a computer simulation program will be developed to analyze pedigree populations. Both genetic linkage and natural selection will be incorporated. As a result, the effect of different rates of inbreeding on inbreeding depression and the conditions for purging a population of lethal alleles will be determined. Furthermore, this technique will be applied to known pedigrees of endangered species to determine the expected inbreeding depression.