1990 Workshop on Site-specific Recombination and Transpostion: September 12-16, 1990, Woods Hole, Massachusetts.

这个研讨会的目的是召集一群精挑细选但具有代表性的科学家进行讨论，他们积极地站在研究特定位点重组和转座所用的生化机制的前沿。这种相互关联的群体反应是许多非常重要的生物学过程的核心：逆转录病毒的整合、抗体多样性的产生、抗生素耐药基因的传递、细菌染色体的重排和真核生物内含子的移动。本研讨会的口头陈述将强调这些重组反应的机制方面。目前在这一领域取得了快速进展，为这一领域的领导人举行一次专门会议应该是及时和富有成效的。发言者名单上包括几位首次将重组分析推向酶动力学领域的科学家，以及许多应用了其他类型的生化、遗传和拓扑分析的科学家。主题将包括逆转录病毒整合、整合酶和分解酶家族的反应、Holliday连接、免疫球蛋白重排、原核转座因子和果蝇P因子。我们还鼓励科学家在尚不适用于机械分析的系统中进行海报演示。这应有助于扩大会议的生物学基础，并鼓励那些在相对不发达的系统中工作的人采取更机械化的办法。会议将限制在100-135人参加。这一数字足以包括在这一领域工作卓有成效的所有主要研究人员，以及合理抽样的博士后研究员和偶尔表现出色的研究生。然而，这个数字足够小，以至于所有参与者之间的有效交换仍然是可能的。

The purpose of this workshop is to assemble for discussions a select but representative group of scientists who are actively working at the forefront of research on the biochemical mechanisms used in site-specific recombination and transposition. This interrelated group reactions lie at the heart of a number of very important biological processes: integration of retroviruses generation of antibody diversity, transmission of antibiotic resistance genes, rearrangement of bacterial chromosomes and mobility of eukaryotic introns. The oral presentations at this Workshop will emphasize the mechanistic aspects of these recombination reactions. There is currently rapid progress in this area, and a specialized meeting for leaders in this field should be both timely and productive. The roster of speakers includes several scientists who have pushed the analysis of recombination for the first time into the realm of enzyme kinetics, as well as many scientists who have applied other types of biochemical, genetic and topological analysis. Topics will include retroviral integration, reactions of the integrase and resolvase families, Holliday junctions, immunoglobulin rearrangements, prokaryotic transposable elements, and Drosophila P elements. We are also encouraging poster presentations from scientists working in systems which are not yet amenable to mechanistic analysis. This should serve both to broaden the biological base of the meeting and to encourage those working in relatively undeveloped systems to undertake a more mechanistic approach. The meeting will be limited to 100-135 participants. This number is sufficient to include all of the principal investigators who are working productively in this area as well as a reasonable sampling of post-doctoral fellows and an occasional outstanding graduate student. However, this number is small enough that efficient interchange amongst all the participants is still possible.