A New Strategy for Mild, Continuous Solution and Solid PhasePeptide Synthesis (U.S.-Egypt Cooperative Science; Science in Developing Countries)

描述：该提案支持马萨诸塞大学的Louis A.Carpino博士与埃及亚历山大大学的两名教职员工(El-Sayed Mansour博士和Ahmed Kassem博士)和一名研究生(El-Faham先生)的合作。项目资金将允许亚历山大大学的团队在卡皮诺博士的实验室工作不同时期，并允许卡皮诺博士对亚历山大大学进行研究访问。埃及团队的高级成员曼苏尔博士将监督亚历山大大学的研究活动，还将在马萨诸塞大学花三个月的时间进行实验室研究。Kassem博士将开始FM醚的合成工作，El-Faham先生将致力于N-FM多肽键保护。卡皮诺博士作为首席调查员，将提供全面的项目监督。范围：这项建议汇集了两个国家在多肽合成和偶联领域工作的研究科学家。预计这项合作研究将产生合成昆虫激素多肽片段的新技术。埃及科学家将有机会熟悉马萨诸塞大学的研究技术和设备，并为该项目的整体成功做出贡献。因此，这项建议实现了发展中国家科学计划通过国际合作交流和转让科学知识的目标。

Description: This proposal supports the collaboration of Dr. Louis A. Carpino, University of Massachusetts, and two faculty members (Drs. El-Sayed Mansour and Ahmed Kassem) and one graduate student (Mr. El-Faham) from the University of Alexandria, Egypt. Project funding will allow the team from the University of Alexandria to work for various periods of time in Dr. Carpino's laboratory and also allow Dr. Carpino a research visit to the University of Alexandria. Dr. Mansour, the senior member of the Egyptian team, will supervise research activities at the University of Alexandria and also spend three months at the University of Massachusetts conducting laboratory studies. Dr. Kassem will initiate work on the synthesis of FM ethers and Mr. El-Faham will work on N-FM peptide bond protection. Dr. Carpino, as Principal Investigator, will provide overall project supervision. Scope: This proposal brings together research scientists from two countries working in the area of peptide synthesis and coupling. It is anticipated that this collaborative research will result in novel techniques for the synthesis of insect hormone peptide segments. The Egyptian scientists will have the opportunity to become familiar with research techniques and equipment at the University of Massachusetts as well as contribute to the overall success of the project. Therefore, this proposal fulfills the objectives of the Science in Developing Countries Program in its exchange and transfer of scientific knowledge through an international collaboration.