Identity of the Tetrodotoxin Receptor

河豚毒素（TTX）是一种天然存在的毒素， 阻断钠离子通道的功能， 神经和肌肉的电兴奋性。 动物中毒 这种麻痹性毒药失去了控制骨骼和 内脏肌肉最终死亡 调查正在 旨在表征钠通道受体， 河豚毒素 不同物种的钠离子通道不同， 结合TTX的能力。 分子的比较 不同物种的结合位点的结构将被制成 以确定具体的组成部分，负责密集 受体的结合特性。 生化和 电生理技术将用于确定 受体的结构。 一旦受体被 确定，将有可能开发药理学试剂 专门针对TTX，导致开发一种 新型麻醉剂

Tetrodotoxin (TTX), a naturally occurring toxin, specifically blocks the function of sodium channels by underlying the electrical excitability in nerve and muscle. Animals poisoned by this paralytic poison lose the ability to control skeletal and visceral muscles and eventually die. The investigation is designed to characterize the sodium channel receptor which binds to tetrodotoxin. Sodium channels in different species differ in their ability to bind TTX. Comparisons of the molecular structure of the binding sites in different species will be made to determine the specific component responsible for the intensive binding properties of the receptor. Biochemical and electrophysiological techniques will be used to determine the structure of the receptor. Once the receptor has been identified, it will be possible to develop pharmacological agents targeted specifically for TTX, leading to the development of a new class of anesthetics.