Chemistry of Transition Metal/Main Group Element Compounds

这一续展奖授予犹他大学，以支持John Gladysz教授的研究，涉及过渡金属/主族元素络合物的结构、成键、动力学行为和反应性。具体地说，将制备、表征和研究手性Re亚硝酰片段与烷基卤化物、酰胺、硫化物和亚硫醚的络合物。手性金属中心将促进不对称有机合成的机理研究和应用的发展。将测试卤代烷基化合物作为不对称烷基化试剂，筛选酰胺基络合物进行不对称去质子化，筛选硫化物络合物不对称氧化成亚硫醚。对过渡金属/主族元素络合物的全面研究将有助于深入了解它们的结构和反应模式，并可能导致各种应用，如固体材料的前体和不对称有机合成的催化剂或试剂。

This renewal award, made to the University of Utah in support of the research of Professor John Gladysz, deals with the structure, bonding, dynamic behavior and reactivity of transition metal/main group element complexes. Specifically, complexes of a chiral rhenium nitrosyl fragment with alkyl halides, amides, sulfides and sulfoxides will be prepared, characterized and their chemistry investigated. The chiral metal center will facilitate mechanistic studies and the development of applications in asymmetric organic synthesis. Alkyl halide complexes will be tested as asymmetric alkylation reagents, amide base complexes will be screened for asymmetric deprotonation and sulfide complexes will be screened for asymmetric oxidation to sulfoxides. %%% A comprehensive study of transition metal/main group element complexes will provide insights into their structure and reactivity patterns and possibly lead to a variety of applications such as precursors to solid-state materials and as catalysts or reagents for asymmetric organic synthesis.