Small Grants for Exploratory Research: Optical Isomer Resolution by Novel Aqueous Two-Phase Systems

许多药物是手性的，也就是说，它们以称为对映异构体的右手和左手分子形式存在。虽然对映体的结构几乎相同，但它们的药理作用却有很大的不同。对于药物开发而言，在临床前和临床试验中研究单个纯对映体的药代动力学影响至关重要。然而，缺乏足够数量的单个立体异构体药物来进行这些试验，以及昂贵的光学分辨分离技术目前是一个瓶颈。本项目的目的是利用各种新发现的新型双水相体系来分辨光学异构体。由于在这些新的水两相体系中形成相的化合物相对便宜，它们将提供一种廉价的技术，通过这种技术可以进行手性分离。为了充分利用它们的潜力，在这些新系统中进行了光学异构体分配的基础研究，目标是通过不同的环境条件来提高分离因子。这是一项探索性研究（SGER）的小额资助，由分离和净化以及界面，传输和热力学项目共同支持。

Many drugs are chiral, that is, they exist in right-and left- handed molecular forms called enantiomers. Although structure is almost identical, enantiomers can differ considerably in their pharmacological effects. For drug development, it is crucial to investigate the pharmacokinetics effects of individual pure enantiomers during preclinical and clinical trials. However, the lack of sufficient quantities of individual stereoisomers drugs for carrying out these trials, and the expensive separation techniques for optical isomer resolution currently represent a bottleneck. The objective of this project is to use a variety of newly discovered novel aqueous two-phase systems for the resolution of optical isomers. Because the phase-forming compounds in these novel aqueous two-phase systems are relatively cheap, they will provide an inexpensive technique by which the chiral separation can be carried out. In order to fully utilize their potential, a fundamental investigation of optical isomer partitioning in these new systems is done with the goal of enhancing the separation factor by varying environmental conditions. This is a Small Grant for Exploratory Research (SGER) jointly supported by the Separation and Purification and the Interfacial, Transport, and Thermodynamics Programs.