U.S.-Japan Cooperative Research (Photoconversion/Photo- synthesis): The Design and Study of Photoreactive Metal Nitrosyl Complexes

该奖项将支持加州大学圣巴巴拉分校化学系Peter Ford教授和日本东京理化学研究所太阳能研究小组Mikio Hoshino博士之间为期两年的美日合作光转化/光合作用研究计划项目。该项目将侧重于研究新的金属有机化合物的基础化学，这些化合物是形成一氧化氮(NO)的光化学前体。一氧化氮是一种已知的心血管扩张剂，近年来被认为是血管内皮细胞衍生的松弛因子，在哺乳动物的神经传递和巨噬细胞的杀菌/杀瘤状态的激活中具有细胞间信使作用。这项合作将汇集美国和日本两个富有成效的研究小组的互补人才和专业知识，研究各种亚硝基金属络合物的合成和光反应行为，长期(推测)目标是了解设计新光动力疗法(PDT)药物所需的基本原理。

This award will support a two-year U.S.-Japan Cooperative Photoconversion/Photosynthesis Research Program project between Professor Peter Ford, Department of Chemistry, University of California, Santa Barbara, and Dr. Mikio Hoshino, Solar Energy Research Group, The Institute of Physical and Chemical Research (RIKEN), Tokyo, Japan. The project will focus on the investigation of the fundamental chemistry of new metallo-organic compounds that are photochemical precursors to nitric oxide (NO) formation. Nitric oxide is a known cardiovascular dilator recently identified as the endothelium-derived relaxing factor in blood vessels and implicated as having an intercellular messenger role in mammalian neural transmission and in the activation of macrophages to the bactericidal/tumoricidal state. The collaboration will bring together the complementary talents and expertise of two very productive research groups in the United States and Japan to investigate the synthesis and photoreaction behavior of a variety of nitrosyl metal complexes with the long term (speculative) goal of understanding fundamental principles necessary for the design of new photodynamic therapy (PDT) drugs.