U.S.-Japan Cooperative Research: Chiral Protonation/ Deprotonation

该奖项将支持为期两年的美国-日本合作科学 Julius Rebek教授，化学系， 马萨诸塞州理工学院，以及古贺教授， 东京大学药学部。 的 项目涉及催化质子转移剂的研究 不对称化学合成 这一合作努力寻求 发展技术和理解的因素， 质子化和去质子化的立体电子学。 这将 需要同时关注质子源和轨道 质子转移。 雷贝克教授在过去的几年里 研究了羧基的立体电子效应， 分子识别化学 古贺教授有一个计划 在不对称去质子化反应和锂化的化学中， 胺碱 他们在这个项目中的合作借鉴了 他们的研究计划的互补性。

This award will support a two-year U.S.-Japan cooperative science project between Professor Julius Rebek, Department of Chemistry, Massachusetts Institute of Technology, and Professor Kenji Koga, Faculty of Pharmaceutical Sciences, University of Tokyo. The project involves the investigation of catalytic proton transfer agents for asymmetric chemical synthesis. This cooperative effort seeks to develop the techniques and understanding of factors governing the stereoelectronics of protonation and deprotonation. This will require a focus on both the proton source as well as the trajectory of proton transfer. Professor Rebek has performed extensive studies of stereoelectronic effects at carboxyl function and the chemistry of molecular recognition. Professor Koga has a program in asymmetric deprotonation reactions and the chemistry of lithiated amine bases. Their collaboration in this project draws on the complementarity of their research programs.