Laser-Excited Lanthanide Ion Luminescence in Chemistry and Biophysics

该项目属于无机、生物无机和有机金属化学项目，重点研究镧系离子发光在镧系能量供体和无机受体之间扩散增强的能量转移。我们的目标是发展对共振交换能量转移的理解，以及对手性镧系和手性无机离子之间能量转移的手性区分的理解。还将研究镧系复合物作为双螺旋DNA探针的插层剂和靶向MRI试剂，进一步研究免疫分析应用的敏化发光的光物理学，以及镧系离子的铁载体和模型铁载体复合物的表征。分子力学/动力学计算将用于指导某些试剂的设计，特别是在手性识别和DNA嵌入中。该项目涉及利用激光照射产生的镧系离子的特殊发光特性来检查各种化学事件，并开发改进的方法，这些方法可能具有研究金属离子-蛋白质和金属离子- dna相互作用的潜力。最终用于临床分析。

This project, in the Inorganic, Bioinorganic and Organometallic Chemistry Program, focusses on the use of lanthanide ion luminescence to investigate diffusion-enhanced energy transfer between lanthanide energy donors and inorganic acceptors. The objective is to develop an understanding of resonant exchange energy transfer previously shown to dominate these systems and of chiral discrimination in the energy transfer between chiral lanthanide and chiral inorganic ions. Also to be examined are lanthanide complexes as intercalation agents for probes of double-helical DNA and as targeted MRI agents, further studies of the photophysics of sensitized luminescence for immunoassay analytical applications, and characterization of siderophore and model siderophore complexes of lanthanide ions. Molecular mechanics/dynamics calculations will be used to direct the design of certain reagents, particularly in chiral recognition and DNA intercalation. %%% This project is concerned with the use of the special luminescence characteristics of lanthanide ions that result from laser irradiation to examine a variety of chemical events and to develop improved methods that may have potential for the study of metal ion-protein and metal ion-DNA interactions, and ultimately for clinical analyses.