Identifying how cortical bone microstructure deteriorates with age

该项目旨在通过整合一系列高分辨率成像，生物力学和计算方法来确定骨骼在衰老过程中逐渐减弱的原因。该项目的预期意义包括对年轻人和老年人骨骼的细胞和亚细胞组织进行全面定义和比较。该国际项目的预期成果包括建立一个新的多学科研究团队，并开发一个新的数据驱动的理论框架，以了解与年龄相关的骨脆性的性质和原因。潜在的长期益处包括治疗与年龄相关的骨质疏松症的新方法。

This project aims to define the disruptions responsible for the gradual weakening of the skeleton in ageing by integrating a range of high-resolution imaging, biomechanical, and computational methods. The expected significance of this project includes a full definition and comparison of the cellular and subcellular organisation of bone from young and elderly individuals. Expected outcomes of this international project include the establishment of a new multidisciplinary research team, and the development of a new data-driven theoretical framework for understanding the nature and the causes of age-related bone fragility. Potential long-term benefits include new ways to treat age-related osteoporosis.