Hindered Transport of Macromolecules in Fibrous Gels

该项目将为预测受阻运输率提供新的理论手段，并为测量运输率提供新的实验方法。通过扩展首席调查员的有效介质理论以包括影响，将在模拟受阻运输方面取得进展局部流体动力和静电相互作用的结果。此外，开发并实现了一种动态模拟球形大分子在纤维床层中运动的方法。模拟将提供一种通用的方法来研究各种纤维构型和溶质纤维相互作用，并将提供可直接与有效介质理论的分析结果相比较的结果。

This project will provide both new theoretical means for predicting rates of hindered transport and new experimental methods for measuring transport rates. Progress in modeling hindered transport will be made by extending the effective medium theory of the Principal Investigator to include the effects of local hydrodynamic and electostatic interactions. In addition, a method for dynamically simulating the motion of a spherical macromolecule in a bed of fibers will be developed and implemented. The simulations will provide a versatile approach to studying a variety of fiber configurations and solute fiber interactions, and will provide results that can be compared directly with the analytical results of the effective medium theory.