Structure and Stability of Membrane-Associated Proteins Complexed with Associating Polymers

膜的结构、相行为和蛋白质稳定性 与缔合聚合物复合的缔合蛋白质， 将通过X射线衍射研究脂质基质的替代 和其他技术。 聚合物-膜蛋白缔合 代表了一种全新的方法， 一类生物分子材料。 第一个膜相关的 待研究的蛋白质基于（i）完整膜蛋白质 (e.g.,细菌视紫红质）和（ii）自组装二维 细菌的表面蛋白层。 两类关联 我们建议考虑的聚合物包括（i） 疏水缔合共聚物，和（ii）离聚物。

The structure, phase behavior, and protein stability of membrane- associated proteins complexed with associating polymers which replace the lipid matrix will be investigated by x-ray diffraction and other techniques. The polymer-membrane protein associations represent a fundamentally new approach aimed at producing a new class of biomolecular materials. The first membrane-associated proteins to be studied are based on (i) integral memebrane proteins (e.g., bacteriorhodopsin) and (ii) self-assembled two-dimensional surface protein layers of bacteria. The two classes of associating polymers which we propose to consider consist of (i) hydrophobically associating copolymers, and (ii) ionomers.