MRI: Development of an Ultra-High Resolution Small Angle X-Ray Scattering Instrument for Characterizing Supramolecular Assemblies

MRI:开发用于表征超分子组装体的超高分辨率小角度 X 射线散射仪器

基本信息

  • 批准号:
    0619171
  • 负责人:
  • 金额:
    $ 43.02万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2006
  • 资助国家:
    美国
  • 起止时间:
    2006-09-01 至 2010-08-31
  • 项目状态:
    已结题

项目摘要

Technical AbstractThe development project is aimed at advancing the design technology for ultra-high-resolution small angle x-ray scattering (SAXS) instrumentation and x-ray optics with broad applications in nanoscale structure characterization. A new optical design concept that can significantly enhance (up to 10-fold) the resolution and signal-to-noise ratio in SAXS measurements will be developed. The superior performance results from a compound optical configuration incorporating both a primary monochromator mirror and a pre-sample secondary focusing mirror to increase resolution and peak intensity. This unique design is expected to supplant the prevalent three-pinhole configuration in current SAXS instruments. The scientific and engineering problems of interest cover a range of multidisciplinary fields including soft condensed matter, biological physics and bioengineering, neuroscience, and bioinorganic chemistry. The instrument will operate out of the x-ray facility of the Materials Research Laboratory, with an established user base of more than 250 researchers from campus, other institutions and local industry. The development should broadly impact the national academic research infrastructure by advancing the optical design and performance of SAXS instrumentation used in diverse research areas in nanoscience and nanotechnology. The investigators of this project will continue their involvement in their numerous outreach programs available at UCSB to improve access to science for diverse groups, including undergraduate and graduate student training, outreach to K-12 students and teachers, and community outreach. Lay AbstractEnhancing structure characterization of nanomaterials is critical to the emerging areas of nanoscience, nanotechnology, and biotechnology. We will develop a laboratory-based microbeam x-ray scattering instrument for discovering the structures of novel new materials on the 1 nanometer to 1000 nanometer scale. The performance of this new instrument will exceed the best commercially available x-ray instrument and will provide a significant enhancement to the campus infrastructure in nanoscience and technology. The development of this cutting edge x-ray characterization tool will establish UCSB as one of strongest institutions in the x-ray characterization area, which will attract users not only from multiple campus groups but also from other research institutions as well. The project provides an excellent training opportunity to graduate students and postdoctoral researchers who will not only participate in building the cutting-edge x-ray tool but also be able to utilize it in a series of research projects which will take advantage of the new capability afforded by the instrument. The x-ray development program will be integrated with the ongoing outreach activities of the principle investigators in mentoring undergraduate students and local high school teachers participating in the large number of ongoing summer internship programs at UCSB.
技术摘要:本项目旨在推进超高分辨率小角度x射线散射(SAXS)仪器和x射线光学的设计技术,在纳米尺度结构表征中具有广泛的应用。将开发一种新的光学设计概念,可以显着提高(高达10倍)SAXS测量中的分辨率和信噪比。优越的性能结果从复合光学配置结合主单色镜和预样品二次聚焦镜,以提高分辨率和峰值强度。这种独特的设计有望取代目前SAXS仪器中流行的三针孔配置。感兴趣的科学和工程问题涵盖了一系列多学科领域,包括软凝聚态物质、生物物理和生物工程、神经科学和生物无机化学。该仪器将在材料研究实验室的x射线设备外运行,拥有来自校园,其他机构和当地工业的250多名研究人员的既定用户群。通过推进用于纳米科学和纳米技术不同研究领域的SAXS仪器的光学设计和性能,这一发展将广泛影响国家学术研究基础设施。该项目的研究人员将继续参与UCSB提供的众多外展项目,以改善不同群体接触科学的机会,包括本科生和研究生培训,面向K-12学生和教师的外展以及社区外展。摘要加强纳米材料的结构表征对纳米科学、纳米技术和生物技术等新兴领域至关重要。我们将开发一种基于实验室的微束x射线散射仪器,用于发现1纳米至1000纳米尺度上的新材料结构。这种新仪器的性能将超过市面上最好的x射线仪器,并将为纳米科学和技术的校园基础设施提供显著的增强。这种尖端的x射线表征工具的开发将使UCSB成为x射线表征领域最强大的机构之一,这不仅将吸引来自多个校园团体的用户,也将吸引来自其他研究机构的用户。该项目为研究生和博士后研究人员提供了一个极好的培训机会,他们不仅可以参与构建尖端的x射线工具,还可以利用该仪器提供的新功能在一系列研究项目中使用它。x射线开发项目将与主要研究人员正在进行的外展活动相结合,以指导参加UCSB大量正在进行的暑期实习项目的本科生和当地高中教师。

项目成果

期刊论文数量(0)
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Cyrus Safinya其他文献

Interactions between Neurofilament SideArms : A Coarse-grained Molecular Dynamics Simulation Study
神经丝侧臂之间的相互作用:粗粒度分子动力学模拟研究
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shinji Matsushita;Cyrus Safinya
  • 通讯作者:
    Cyrus Safinya
Mechanical Behaviors of Neurofilament Sidearms : A Coarse-grained Molecular Dynamics Simulation Study
神经丝侧臂的机械行为:粗粒度分子动力学模拟研究
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Shinji Matsushita;Cyrus Safinya
  • 通讯作者:
    Cyrus Safinya

Cyrus Safinya的其他文献

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{{ truncateString('Cyrus Safinya', 18)}}的其他基金

Biomolecular Materials: Structure, Phase behavior, and Interactions
生物分子材料:结构、相行为和相互作用
  • 批准号:
    1807327
  • 财政年份:
    2018
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Standard Grant
Biomolecular Materials: Structure, Phase Behavior, & Interactions
生物分子材料:结构、相行为、
  • 批准号:
    1401784
  • 财政年份:
    2014
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Continuing Grant
Biomolecular Materials: Structure, Phase Behavior, & Interactions
生物分子材料:结构、相行为、
  • 批准号:
    1101900
  • 财政年份:
    2011
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Standard Grant
Biomolecular Materials: Structure, Phase Behavior, & Interactions
生物分子材料:结构、相行为、
  • 批准号:
    0803103
  • 财政年份:
    2008
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Continuing Grant
Biomolecular Materials: Structure, Phase Behavior, & Interactions
生物分子材料:结构、相行为、
  • 批准号:
    0503347
  • 财政年份:
    2005
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Continuing Grant
Biomolecular Materials: Structure, Phase Behavior, and Interactions
生物分子材料:结构、相行为和相互作用
  • 批准号:
    0203755
  • 财政年份:
    2002
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Continuing Grant
Development of a Short Wavelength Spectroscopic X-ray Microscope for Advanced Materials Research and Student Training
开发用于先进材料研究和学生培训的短波长光谱 X 射线显微镜
  • 批准号:
    0076357
  • 财政年份:
    2000
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Continuing Grant
Biomolecular Materials: Structure, Phase Behavior and Interactions
生物分子材料:结构、相行为和相互作用
  • 批准号:
    9972246
  • 财政年份:
    1999
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Continuing Grant
Acquisition of Optical Imaging Instrumentation for Biomolecular and Complex Materials Characterization
获取用于生物分子和复杂材料表征的光学成像仪器
  • 批准号:
    9724254
  • 财政年份:
    1997
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Standard Grant
Biomolecular Materials: Structure, Phase Behavior, and Interaction
生物分子材料:结构、相行为和相互作用
  • 批准号:
    9624091
  • 财政年份:
    1996
  • 资助金额:
    $ 43.02万
  • 项目类别:
    Continuing Grant

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