Biomolecular Materials: Structure, Phase Behavior, & Interactions

生物分子材料：结构、相行为、

• 批准号: 0503347
• 负责人: Cyrus Safinya
• 金额: $ 36万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0503347&HistoricalAwards=false
• 关键词: Biomolecular; Materials; Structure; Phase; Behavior

The project is expected to elucidate the key parameters that control the interactions between proteins derived from the cell cytoskeleton, which lead to hierarchical supramolecular structures on the nanometer to micron scale. Experiments with custom synthesized macromolecular counter-ions with defined chemical structure, will distinguish between the differing roles of charge and size of the counter-ion in controlling intermolecular interactions. Peptide-based counter-ions will be used to clarify the role of the shape of the counter-ion on the symmetry of the self-assembly. From a broader perspective, the research will lead to the rather exciting and formidable task of unraveling the biophysics of the cell cytoskeleton. The elucidation of the basic rules of assembly of filamentous proteins has potential for developing novel miniaturized materials for the 21st century. The multidisciplinary project integrates research and education in order to train students and postdoctoral researchers in modern methods required to address important problems at the interface between physics, biology, chemistry, and engineering with potential applications in biotechnology and nanotechnology.%%%%%The project centers on discovering the key parameters that control the interactions and forces between proteins, which are used as the building blocks of the skeleton of cells. To a large extent Nature uses electrostatic forces to assemble its building blocks in distinct shapes and sizes for specific functions. The learned concepts should lead to the exciting possibility of developing advanced nanometer scale materials for nanoscience applications in the electronic, chemical, and pharmaceutical industries. The multidisciplinary project integrates research and education in order to train students and postdoctoral researchers in modern methods required to address important problems at the interface between physics, biology, chemistry, and engineering with potential applications in biotechnology and nanotechnology. The acquired interdisciplinary skills, which include synchrotron x-ray diffraction at National Facilities and state-of-the-art optical and electron microscopy methods, prepare the trainees for careers in academe, national laboratories, and industry.

该项目预计将阐明控制来自细胞骨架的蛋白质之间相互作用的关键参数，从而导致纳米至微米尺度的分级超分子结构。 使用具有定义化学结构的定制合成大分子抗衡离子的实验将区分抗衡离子的电荷和大小在控制分子间相互作用中的不同作用。 基于肽的抗衡离子将用于澄清抗衡离子的形状对自组装的对称性的作用。 从更广泛的角度来看，这项研究将导致相当令人兴奋和艰巨的任务，解开细胞骨架的生物物理学。 阐明丝状蛋白质组装的基本规则，对于开发21世纪新型微型材料具有潜在意义。 该多学科项目整合了研究和教育，以培养学生和博士后研究人员掌握现代方法，以解决物理学，生物学，化学和工程之间的重要问题，并在生物技术和纳米技术中具有潜在的应用。该项目的重点是发现控制蛋白质之间相互作用和作用力的关键参数，这些蛋白质被用作细胞骨架的构建块。 在很大程度上，自然界利用静电力将其积木组装成不同形状和大小的特定功能。 所学到的概念应该导致开发先进的纳米尺度材料在电子，化学和制药工业中的纳米科学应用的令人兴奋的可能性。 该多学科项目整合了研究和教育，以培养学生和博士后研究人员在现代方法所需的物理，生物，化学和工程与生物技术和纳米技术的潜在应用之间的接口解决重要问题。 获得的跨学科技能，其中包括国家设施的同步加速器X射线衍射和最先进的光学和电子显微镜方法，为学员在国家实验室，国家实验室和工业中的职业生涯做好准备。