Biomolecular Materials: Structure, Phase Behavior, and Interaction

生物分子材料：结构、相行为和相互作用

• 批准号: 9624091
• 负责人: Cyrus Safinya
• 金额: $ 25.5万
• 依托单位: University of California-Santa Barbara
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-15 至 2000-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=9624091&HistoricalAwards=false
• 关键词: Biomolecular; Materials; Structure; Phase; Behavior

w:\awards\awards96\*.doc 9624091 Safinya The structure of artificially developed self assembled membrane-associating-proteins and peptides in multilayers will be characterized by synchrotron x-ray diffraction techniques. The objective is to elucidate protein-protein interactions in these artificial self assemblies and to develop a new class of advanced materials consisting of functionalized interfaces manipulated at the molecular level. This should lead to advanced materials useful in optical, separations, chemical sensors, and high temperature catalysis applications. We will explore the structure and hydrogel behavior in a newly invented class of lamellar hydrogels based on fluid membranes and end-anchored polymer-lipids. "bioactive lamellar gels" useful in tissue healing or drug delivery applications will be developed with activity derived from biomolecules and mechanical stability from the polymer-lipid component. %%% This project seeks to develop a new class of materials consisting of multilayers of functionalized interfaces which can be manipulated at the molecular level. The components of these materials will consist of surfactants (surface active molecules), proteins, and peptides. The materials should be useful in molecular separations and purification technologies, biological and chemical sensors technologies, and high temperature catalysis applications. A new class of recently invented hydrogels invented in this laboratory will be explored further. The lamellar gels are made from liquid phases by the addition of water, a highly unusual behavior. Because the gels contains no solid component they have the potential of incorporating combinations of biologically active molecules. We will explore the development of "bioactive lamellar gels" useful in artificial tissue development, in tissue healing, and in drug delivery applications. ***

w：\awards\awards96\*.doc 小行星9624091 的 结构 的 人工开发的 自我 将通过同步加速器X射线衍射技术表征多层中组装的膜缔合蛋白质和肽。 目的是阐明这些人工自组装蛋白质-蛋白质相互作用，并开发一类新的先进材料，包括在分子水平上操纵的功能化界面。 这将导致在光学，分离，化学传感器和高温催化应用中有用的先进材料。我们将探讨在一个新发明的层状水凝胶类的结构和水凝胶行为 基于 对 流体 膜 和 末端锚定的聚合物-脂质。 可用于治疗癌症的“生物活性层状凝胶” 组织愈合或药物递送应用将被开发为具有源自生物分子的活性和来自聚合物-脂质组分的机械稳定性。 该项目旨在开发一种新的材料， 多层功能化界面，其可以 在分子水平上进行操纵。这些材料的组分将由表面活性剂（表面活性分子）、蛋白质和肽组成。 该材料应可用于分子分离和纯化技术、生物和化学传感器技术以及高温催化应用。本实验室最近发明的一类新的水凝胶将被进一步研究。层状凝胶是由液相加水制成的，这是一种非常不寻常的行为。因为凝胶不含固体成分， 有可能将 有生物活性的分子。我们将探索开发“生物活性 层状 凝胶” 有用 在 人工 组织发育， 在 组织 治愈， 和 在 药物 交付应用程序。 ***