Synthesis of Ligands to Control Catalyst Homogeneity and Miscibility

本研究的重点是利用配体控制催化剂的均匀性和混溶性。首先，将制备具有反温度依赖性溶解度的聚合物配体。目标是使用大分子配体来连接金属并调节反应。其次，低聚配体将被设计为提供或有助于催化剂周围的溶剂微环境，以减轻散装溶剂的影响。第三，将研究大分子在共同溶剂中相分离可溶性物质的能力。最后，对增强立体选择性的手性高分子配体进行了研究。有了这个奖，合成有机项目就支持了德克萨斯农工大学化学系的大卫·e·伯格布雷特博士的研究。Bergbreiter教授将专注于利用可溶性大分子的性质来设计控制均相催化剂物理性质的配体。总的思路是了解可溶聚合物的物理化学性质是否能有效地控制均相催化剂的均相性和混相性。

The focus of this research is the use of ligands to control catalyst homogeneity and miscibility. First, polymeric ligands will be prepared that have inverse temperature dependent solubility. The goal is to use a macromolecular ligand to both ligate a metal and to regulate a reaction. Second, oligomeric ligands will be designed to provide or contribute to the solvent microenvironment around a catalyst so that the effects of bulk solvent are mitigated. Third, macromolecules will be studied for the ability to phase isolate soluble species from one another in a common solvent. Finally, chiral macromolecular ligands that enhance stereoselectivity will be studied. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. David E. Bergbreiter of the Department of Chemistry at Texas A&M University. Professor Bergbreiter will focus his work on using the properties of soluble macromolecules to design ligands that control the physical properties of homogeneous catalysts. The general idea is to learn if the physiochemical properties of soluble polymers can control a homogeneous catalyst's homogeneity and miscibility in useful ways.