Acquisition of an EPR Spectrometer

购买一台多机构、多用户的EPR光谱仪，安置在克拉克大学化学系，将补充位于同一大楼的伍斯特财团磁共振中心，为整个新英格兰中部的机构提供生物和化学研究设施。新英格兰共有十所教育机构参加。提出了5个生物医学重点专项研究项目和3个理化重点专项研究项目，并提出了若干次专项研究项目。主要用户提出：赖氨酸氧化酶及相关含铜胺氧化酶的结构和作用机制的研究；抗原蛋白片段进入主要组织相容性复合体分子抗原结合位点的选择和转移的调控结构和机制；改进EPR剂量计技术，重点是使用骨髓和骨碎片作为原位剂量计；细胞色素P-450单加氧酶介导的氯碳毒性机制；金属结合对神经化学重要蛋白钙调蛋白构象及与细胞内靶酶和抑制蛋白相互作用的影响；透明双金属层状铁磁体系的低温磁性能存在于水溶液和电极表面的自由基硫的性质；线性反铁磁链的量子效应。

9222752 Greenaway The purchase of a multi-institutional, multi-user EPR spectrometer to be housed in the Department of Chemistry at Clark University will complement the Worcester Consortium Center for Magnetic Resonance, located in the same building, to provide facilities for biological and chemical research for institutions throughout Central New England. A total of ten educational institutions throughout New England are represented. Five specific research projects of biomedical emphasis and three of physico-chemical emphasis are proposed, as well as a number of secondary projects. The major users propose studies of: the structure and mechanism of action of lysyl oxidase and related copper-containing amine oxidases; the structures and mechanisms regulating selection and transfer of fragments of antigenic proteins into the antigen- binding sites of major histocompatibility complex molecules; the improvement of EPR dosimetric techniques with emphasis on the use of bone marrow and bone fragments as in situ dosimeters; the cytochrome P-450 monooxygenase-mediated mechanisms of toxicity of chlorocarbons; the effects of metal-binding in the neurochemically- important protein calmodulin on conformation and interactions with intracellular target enzymes and inhibitor proteins; the low-temperature magnetic properties of transparent bimetallic layered ferrimagnetic systems; the nature of the radical sulfur species present in aqueous solutions and at electrode surfaces; quantum effects n linear antiferromagnetic chains.