FASEB Summer Research Conference: Genetic Recombination and Genome Rearrangements to be held at Copper Mountain, Colorado from July 25-30, 1993

9302546 Rothstein这项拨款为FASEB基因重组和基因组重排夏季研究会议提供了部分资金，该会议将于1993年7月25日至30日在CO. Copper Mountain举行。该会议由美国实验生物学学会联合会（FASEB）主持。本次会议的形式将与戈登研究会议相同。将有9个主要会议，邀请36位演讲者。每届会议的主席将就历史背景和当前问题作介绍性发言，使所有与会者熟悉该届会议的主题。会议期间将举行海报发布会。在会议之前或会议期间将安排非正式的小组讨论会。主题将涵盖从哺乳动物细胞到细菌的广泛生物。将介绍体内和体外方法。该会议是美国唯一定期召开的专门讨论基因重组和基因组重排的会议。本次会议将讨论的主题包括基因治疗的当前方法、导致癌症和其他疾病的基因组重排、连锁分析中的问题、同源重组的遗传学、同源重组的酶学（链转移酶、核酸酶和分解酶）、重组中间体的物理结构、异双工重组中间体中错配位点的修复、位点特异性重组和基因表达的调控。以及细菌和真核生物的转位。这次会议为对重组的基本机制方面感兴趣的科学家和对实际应用感兴趣的科学家提供了一个重要的接口，例如基因治疗、动物疾病模型的创建和基因组重塑以测试基因调控序列的功能改变。* * *

9302546 Rothstein This grant provides partial funding for a FASEB Surnmer Research Conference on Genetic Recombination and Genome Rearrangements, which is being held July 25 to July 30, 1993 in Copper Mountain, CO. The conference is under the auspices of the Federation of the American Societies of Experimental Biology (FASEB). The format of this meeting will be the same as that used by the Gordon Research Conferences. There will be nine major sessions with 36 invited speakers. The chairperson of each session will give an introductory talk on the historical background and the current problems to acquaint all participants with the topics in that session. Poster sessions will be held throughout the meeting. Informal workshops of small groups will be arranged before or at the meeting. Topics will cover a broad range of organisms from mammalian cells to bacteria. Both in vivo and in vitro approaches will be presented. This conference is the only regularly scheduled meeting in the United States that is devoted exclusively to genetic recombination and genome rearrangements. The topics to be covered at this meeting are current approaches to gene therapy, genome rearrangements that lead to cancer and other diseases, problems in linkage analysis, genetics of homologous recombination, enzymology of homologous recombination (strand transferases, nucleases, and resolvases), physical structure of recombination intermediates, repair of mismatch sites in heteroduplex recombination intermediates, site-specific recombination and regulation of gene expression, and bacterial and eukaryotic transposition. %%% This meeting provides a crucial interface between scientists interested in the basic mechanistic aspects of recombination and those interested in practical applications, such as gene therapy, creation of animal models of disease, and remodeling of genomes to test functional alterations of gene regulatory sequences. ***