U.S.-Korea Cooperative Research on Development of Empirical Potential Functions for Protein Folding

该奖项将资助康奈尔大学化学系Harold a . Scheraga博士与韩国科学技术院（KAIST）化学系Mu Shik Jhon教授和韩国宋实大学化学系Kyoung Tai No博士进行为期36个月的合作研究项目，以开发蛋白质折叠的经验势能功能。本理论研究旨在阐明多肽链折叠成蛋白质天然构象的能量和机制。虽然目前合作者开发的势函数对于一些应用来说已经足够精确，但合作者将开发新的更好的势函数，这些势函数将具有更大的适用性。这项研究对于更好地理解蛋白质的结构和性质具有重要意义。合作者是该提案领域中备受尊敬的研究人员。该项目与美韩合作科学项目的目标相关，该项目旨在通过科学信息、思想、技能和技术的交流以及在互利问题上的合作，提高美韩科学家和工程师之间的合作水平。韩国参与该项目得到了韩国科学工程财团（KOSEF）的支持。该项目在美国国家科学基金（NSF）资助下为PI的研究增加了一个国际合作的维度。dmb - 9015815。＊＊＊

9306345 Scheraga This award provides funds to permit Dr. Harold A. Scheraga, Department of Chemistry, Cornell University, to pursue with Professor Mu Shik Jhon, Department of Chemistry, Korea Advanced Institute of Science and Technology (KAIST), and Dr. Kyoung Tai No, Department of Chemistry, Soong-Sil University, Korea, for 36 months, a program of cooperative research on the development of empirical potential functions for protein folding. This theoretical research is designed to elucidate the energies and mechanism of the folding of a polypeptide chain into the native conformation of a protein. While current potential functions, developed by the collaborators, are sufficiently accurate for several applications, the collaborators will develop new and better potential functions which will have greater applicability. This research is important for developing a better understanding of the structure and properties of proteins. The collaborators are highly respected researchers in the field of the proposal. This project is relevant to the objectives of the U.S.-Korea Cooperative Science Program which seeks to increase the level of cooperation between U.S. and Korean scientists and engineers through the exchange of scientific information, ideas, skills, and techniques and through collaboration on problems of mutual benefit. Korean participation in the project is supported by the Korea Science and Engineering Foundation (KOSEF). This project adds an international cooperative dimension to the PI's research under NSF Grant No. DMB-9015815. ***