Synthesis of Carbocyclic and Heterocyclic Natural Products

9316939白色这项研究的重点是发现新的合成方法，并将其应用于某些天然来源的碳环和杂环化合物的合成。为了确定项目的具体目标，确定了五种天然产品。它们分为两组，一组由涉及环丁烷的键重组为重点步骤组成，另一组由杂环亚单位的精加工起关键作用。第一组含有红曲霉毒素B、魔芋毒素和石杉碱甲。第二组含有生物碱圆柱状精液蛋白和库明。在所有的合成中，主要强调的是能够完成到包含高度复杂性的结构的有效路线的能力。有了这个奖项，合成有机计划支持俄勒冈州立大学化学系的詹姆斯·D·怀特博士的研究。怀特教授将专注于发现新的合成方法，并将其应用于合成某些天然来源的碳环和杂环化合物。指定的目标化合物的分子结构对当代合成方法提出了重大挑战，将通过探索非常规的、在某些情况下前所未有的方法来解决这一问题。***

9316939 White The focus of this research is the discovery of new synthetic methods and their application to the synthesis of certain carbocyclic and heterocyclic compounds of natural origin. Five natural products are identified for the purpose of defining the specific goals of the project. They fall into two groups, one consisting of a set for which bond reorganization involving a cyclobutane is the focal step, and another in which elaboration of a heterocyclic subunit plays a pivotal role. The first group contains rubratoxin B, verrucarol, and huperzine A. The second group contains the alkaloids cylindrospermopsin and koumine. The major emphasis in all of the syntheses is the ability to complete efficient routes to structures containing a high degree of complexity. %%% With this award, the Synthetic Organic Program is supporting the research of Dr. James D. White of the Department of Chemistry at Oregon State University. Professor White will focus his work on the discovery of new synthetic methods and their application to the synthesis of certain carbocyclic and heterocyclic compounds of natural origins. The molecular architecture of the designated target compounds presents a significant challenge to contemporary methods of synthesis which will be addressed by exploring unconventional and, in several instances, unprecedented approaches to their construction. ***