Synthesis of Triply Hydrogen Bonded Complexes

在有机动力学项目的资助下，科尔盖特大学的Nolen教授将利用自组装程序构建基于三氢键结合的结构明确的超分子复合物。一个主要的目标是合成一个自组装的大环结构，包含六个组成部分，被称为超分子己螺母。本科生将参与这些化合物的合成和表征，并通过核磁共振、紫外/可见、荧光、气相渗透测定法和凝胶渗透色谱法研究它们的性质。各种大型的、复杂的有机化合物将被制造出来，这些化合物通过相互作用具有独特的结合性质，这种相互作用被称为非共价键。这些结构将模仿分子的行为，如DNA，也通过非共价键结合。对这种非共价相互作用的理解将使科学家能够设计出能够自我复制的新化合物，并增强对包括能量转移、复制和酶催化在内的生化过程的理解。

9403497 Nolen Colgate University With funding from the Organic Dynamics Program Professor Nolen of Colgate University will construct using self-assembly procedures structurally well-defined supramolecular complexes based upon triply hydrogen bonded associations. A primary goal is the synthesis of a self-assembled macrocyclic structure containing six components that is called a supramolecular hexnut. Undergraduates will be involved in the synthesis and characterization of these compounds and their properties will be studied by NMR, UV/vis, fluorescence,vapor phase osmometry, and gel-permeation chromatography. A variety of large, complex organic compounds will be made that have the unique properties of association by interactions that are called non-covalent bonds. These structures will mimic the behavior of molecules like DNA that also associate through non-covalent bonds. An understanding of this non-covalent interaction will allow scientists to design new compounds that can self replicate and enhance understanding of biochemical processes including energy transfer, replication, and enzyme catalysis.