Time to shine for constrained peptides as next-generation pharmaceuticals

目前用于筛选和产生多肽和蛋白质药物的方法费力、昂贵，而且往往与制药工业中使用的生物系统不兼容。利用化学和分子生物学方面的最新进展，该项目旨在改进基于多肽的药物的设计、合成和筛选。主要研究成果是用于筛选大型多肽文库的创新的生物相容化学转化，以释放受限制多肽在药物开发中的革命性潜力。预期的好处是用于快速生产生物活性分子的可靠和具有成本效益的技术，以供未来用于人类和农业药物。

Current methods for the screening and generation of peptide and protein drugs are laborious, expensive and often incompatible with the biological systems used in pharmaceutical industries. Leveraging recent advancements in chemistry and molecular biology, this project aims to improve the design, synthesis and screening of peptide-based pharmaceuticals. Key research outcomes are innovative biocompatible chemical transformations for the screening of large peptide libraries, to unleash the revolutionary potential of constrained peptides in drug development. Expected benefits are reliable and cost-effective technologies for the rapid production of biologically active molecules for future targeted use in human and agricultural pharmaceuticals.