Metal-Mediated Oxygen-, Sulfur- and Nitrogen-Transfer Reactions

该奖项在无机，生物无机和有机化学计划支持研究硫，氧和氮转移反应的博士。加州大学伯克利分校化学系的伯格曼说。 将研究能够在有机分子和金属中心之间转移硫、氧和烷基化氮等杂原子的过渡金属配合物。 初步工作将集中在有机钽络合物，从三元有机环化合物中除去这些原子和基团，产生烃和具有杂原子-金属多重键的新金属络合物。 在这一初始阶段之后，该项目将确定这些反应的机理，以准备确定其他金属络合物，这些金属络合物可以反向催化这些反应，从而产生可以将烯烃转化为环氧化物、硫杂环丙烷和氮杂环丙烷等物质的络合物。 有机分子和过渡金属中心之间的硫、氧和氮等杂原子的转移是有机和生物酶化学中的基本化学过程。 这些结果将有助于设计在化学和制药工业中用于有机合成的反应，以及从燃料中去除硫、氧和氮的方法，从而减少来自该来源的对环境有害的硫和氮氧化物的产生。

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program supports research on sulfur, oxygen, and nitrogen transfer reactions by Dr. Robert G. Bergman of the Department of Chemistry, University of California-Berkeley. Transition metal complexes capable of transferring heteroatoms, such as sulfur, oxygen, and alkylated nitrogen, between organic molecules and metal centers will be studied. Initial work will focus on organotantalum complexes which remove these atoms and groups from three-membered organic ring compounds, creating hydrocarbons and new metal complexes with heteroatom-metal multiple bonds. After this initial phase, the project will define the mechanism of these reactions in preparation for identifying other metal complexes which can run these reactions in reverse catalytically, thus generating complexes which can convert alkenes into species such as epoxides, thiiranes and aziridines. The transfer of heteroatoms such as sulfur, oxygen, and nitrogen between organic molecules and transition metal centers is a fundamental chemical process in organic and biological enzyme chemistry. The results should lead to the design of reactions useful in organic synthesis in the chemical and pharmaceutical industries, and to methods for removal of sulfur, oxygen, and nitrogen from fuels, thus reducing production of environmentally harmful sulfur and nitrogen oxides from this source.