Organic and Organometallic Chemistry

这个无机、生物无机和有机金属化学项目的奖项支持加州大学伯克利分校的Robert G. Bergman教授的研究，该研究利用新的和已知的带有金属杂原子单键的晚期过渡金属配合物，获得了金属配合物和有机化合物在均相溶液中反应的基本机理理解。该项目建立在合成母体（即n -未取代）低价晚期过渡金属酰胺配合物的潜在通用方法的基础上，并将其扩展到涉及氮或磷的其他方法。具体研究目标包括：(a)更广泛的母体金属酰胺的合成和研究；(b)相关化合物的制备，如金属肼配合物及其反应性的研究；(c)催化烯烃和炔氢胺化的新方法的发展；(d)金属酰胺在选择性合成伯胺中的应用；(e)金属酰胺催化异构化反应的研究。(f)将氨基化学的方法扩展到母体磷酸配合物的合成，包括它们在不对称合成p -致氮膦中的应用。这些项目将由本科生、研究生和博士后进行，他们在研究过程中获得的训练将对他们未来的工作有用。本研究探讨了均相催化的基本方面，为本科生、研究生和博士后参与先进的科学工作做好准备。

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Robert G. Bergman at the University of California at Berkeley to obtain a basic mechanistic understanding of the reactions of metal complexes and organic compounds in homogeneous solution using both new and known late transition metal complexes that bear metal-heteroatom single bonds. The project builds on potentially general methods for the synthesis of parent (i.e., N-unsubstituted) low-valent, late transition metal amide complexes and extend it to others involving nitrogen or phosphorus. Specific research goals include: (a) the synthesis and study of a wider range of parent metal amides, (b) the preparation of related compounds, such as metal hydrazido complexes and an examination of their reactivity, (c) the development of new methods for catalytic alkene and alkyne hydroamination, (d) the use of metal amides in the selective synthesis of primary amines, (e) the study of metal amide-catalyzed isomerization reactions, and (f) the extension of methods developed in amido chemistry to the synthesis of parent phosphido complexes, including their use in the asymmetric synthesis of P-chirogenic phosphines. The projects will be carried out by undergraduate students, graduate students and postdoctoral fellows whose training obtained during the performance of this research will be useful in their future work.This research probes fundamental aspects of homogeneous catalysis and prepares undergraduate, graduate and postdoctoral students for participation in the advanced scientific workforce.