Organic and Organometallic Chemistry

有机和有机金属化学

• 批准号: 0345488
• 负责人: Robert Bergman
• 金额: --
• 依托单位: University of California-Berkeley
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0345488&HistoricalAwards=false
• 关键词: Organic; Organometallic; Chemistry

This award in the Inorganic, Bioinorganic and Organometallic Chemistry program supports research by Professor Robert G. Bergman at the University of California at Berkeley to obtain a basic mechanistic understanding of the reactions of metal complexes and organic compounds in homogeneous solution using both new and known late transition metal complexes that bear metal-heteroatom single bonds. The project builds on potentially general methods for the synthesis of parent (i.e., N-unsubstituted) low-valent, late transition metal amide complexes and extend it to others involving nitrogen or phosphorus. Specific research goals include: (a) the synthesis and study of a wider range of parent metal amides, (b) the preparation of related compounds, such as metal hydrazido complexes and an examination of their reactivity, (c) the development of new methods for catalytic alkene and alkyne hydroamination, (d) the use of metal amides in the selective synthesis of primary amines, (e) the study of metal amide-catalyzed isomerization reactions, and (f) the extension of methods developed in amido chemistry to the synthesis of parent phosphido complexes, including their use in the asymmetric synthesis of P-chirogenic phosphines. The projects will be carried out by undergraduate students, graduate students and postdoctoral fellows whose training obtained during the performance of this research will be useful in their future work.This research probes fundamental aspects of homogeneous catalysis and prepares undergraduate, graduate and postdoctoral students for participation in the advanced scientific workforce.

无机化学、生物无机化学和金属有机化学项目的这一奖项支持了加州大学伯克利分校的罗伯特·G·伯格曼教授的研究，他的研究旨在通过使用新的和已知的带有金属-杂原子单键的后过渡金属络合物，从基本机理上了解金属络合物和有机化合物在均相溶液中的反应。该项目建立在潜在的合成母体(即N-未取代)低价、后过渡金属酰胺络合物的一般方法的基础上，并将其扩展到其他涉及氮或磷的化合物。具体的研究目标包括：(A)更广泛的母体金属酰胺的合成和研究，(B)相关化合物的制备，如金属酰肼络合物的制备和反应活性的考察，(C)开发催化烯烃和炔氢胺化的新方法，(D)金属酰胺在伯胺的选择性合成中的使用，(E)金属酰胺催化的异构化反应的研究，以及(F)将酰胺化学中发展的方法扩展到母体磷化物的合成，包括它们在不对称合成P-甲基膦方面的应用。这些项目将由本科生、研究生和博士后研究员进行，他们在这项研究中获得的培训将对他们未来的工作有所帮助。本研究探索了均相催化的基本方面，并为本科生、研究生和博士后参与高级科学工作做好准备。