Organic and Organometallic Chemistry

加州大学伯克利分校化学系罗伯特·G·伯格曼博士受到化学部无机化学、生物无机化学和金属有机化学项目的支持，该项目研究均相溶液中的有机金属反应机理。重点抓好三个项目。一是系统地介绍了晚期金属杂原子配合物的合成及其与有机物反应机理的研究进展。金属-氧和-氮单键的基础化学，氢/杂原子转移反应，以及金属-杂原子络合物中电负性原子的碱性都是需要研究的课题。第二部分详细研究了Rh催化的环氧化物氢甲酰化反应。将包括其他三个成员环系统的氢甲酰化反应，希望开发出各种有用的有机产品的新的、方便的路线。第三，将研究金属有机化合物与自由原子和亚稳态硅原子的反应。重点将放在那些在有机化学中开辟了新途径，但尚未被广泛应用于有机金属体系的物种上。涉及有机分子和过渡金属络合物的化学反应是理解重要的催化和生物过程的基础。这项研究将拓展金属-有机相互作用的基础化学知识，应用于更复杂的体系，并有助于在合成和催化化学中开发新的实际应用。

Dr. Robert G. Bergman, Chemistry Department, University of California at Berkeley is supported by the Inorganic, Bioinorganic, and Organometallic Chemistry Program of the Chemistry Division for studies of organometallic reaction mechanisms in homogeneous solution. Efforts will be focused on three projects. The first is a systematic development of the synthesis of late-metal-heteroatom complexes and studies of the mechanisms of the reactions of these compounds with organic substances. Fundamental chemistry of metal-oxygen and -nitrogen single bonds, hydrogen/heteroatom transfer reactions, and the basicity of the electronegative atom in metal-heteroatom complexes are among the topics to be investigated. The second section is a detailed study of the rhodium catalyzed hydroformylation of epoxides. The hydroformylation of other three member ring systems will be included with hopes of developing new, convenient routes to a variety of useful organic products. Thirdly, the reactions of organometallic compounds with free atoms and metastable diatomics will be investigated. The emphasis will be on species that have opened new pathways in organic chemistry, but have not been much applied to organometallic systems. Chemical reactions involving organic molecules and transition metal complexes are fundamental to the understanding of important catalytic and biological processes. This research will expand the fundamental chemical understanding of metal-organic interactions, be applied to more complicated systems, and aid the development of new practical applications in synthetic and catalytic chemistry.