Organic and Organometallic Chemistry

该奖项授予无机化学、生物无机化学和金属有机化学项目，为加州大学伯克利分校化学系罗伯特·G·伯格曼博士在有机分子与过渡金属络合物反应方面的工作提供持续支持。一个研究领域是合成含有两种金属的新络合物，这些金属相互靠近。特别针对的是不对称的体系，这是由于两种具有非常不同电子性质的金属的存在，或者由于每个金属中心存在不同的反应配体。对这些材料的研究将集中在适用于烯烃、炔烃和二氧化碳等有机小分子的化学利用的反应，以及适用于有机合成中重要的转化类型，如碳-碳或碳-杂原子键的形成。第二个研究领域是有机金属物种的产生，这些物种由于金属中心存在未配对的电子，即有机金属自由基而具有高度活性，并能够与金属形成相对较强的共价键。此外，将开发从相对不酸性的金属氢化物中提取质子的方法，以生成非常亲核的低价阴离子金属络合物。许多人都知道发生在偶电子络合物中的有机金属反应，这些络合物包含一个金属中心，很容易接触到电荷和氧化态。这个项目超越了这些研究领域，以了解涉及奇数个电子、不常见的金属氧化态或多个金属中心的情况下的反应细节。这些结果将增加对与化学制造相关的反应的理解

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program provides continued support to work by Dr. Robert G. Bergman of the Chemistry Department, University of California at Berkeley, on reactions of organic molecules with transition metal complexes. One area of investigation is the synthesis of new complexes containing two metals located in close proximity to one another. Specifically targeted are systems that are unsymmetrical, due to either the presence of two metals with very different electronic properties or to the presence of different reactive ligands at each metal center. Research on these materials will focus on reactions that are applicable to the chemical utilization of small organic molecules, such as alkenes, alkynes and carbon dioxide, and to the type of transformations important in organic synthesis, such as carbon-carbon or carbon-heteroatom bond formation. A second area of investigation is the generation of organometallic species that are highly reactive due to the presence of an unpaired electron at the metal center, that is, organometallic free radicals, and capable of forming a relatively strong covalent bond to the metal. Also, methods for the abstraction of protons from relatively unacidic metal hydrides will be developed in order to generate very nucleophilic, low valent anionic metal complexes. Much is known about organometallic reactions that take place in even-electron complexes that contain a single metal center with easily accessible charges and oxidation states. This project moves beyond these areas of investigation to obtain understanding of reaction details in cases involving an odd-number of electrons, uncommon metal oxidation states, or more than one metal center. The results will increase understanding of reactions which are relevant to chemical manufacturing