Organic and Organometallic Chemistry

这个无机、生物无机和有机金属化学项目的奖项为加州大学伯克利分校化学系的Robert G. Bergman博士在有机分子与过渡金属配合物的反应方面的工作提供了持续的支持。研究的一个领域是合成含有两种彼此靠近的金属的新配合物。特别针对的是不对称的体系，因为要么存在两种电子性质非常不同的金属，要么在每个金属中心存在不同的反应配体。对这些材料的研究将集中于适用于小有机分子的化学利用的反应，如烯烃、炔烃和二氧化碳，以及有机合成中重要的转化类型，如碳-碳或碳杂原子键的形成。第二个研究领域是有机金属的产生，由于在金属中心存在不成对的电子，即有机金属自由基，并且能够与金属形成相对较强的共价键，因此具有高活性。此外，从相对非酸性金属氢化物中提取质子的方法也将得到发展，以生成亲核性很强的低价阴离子金属配合物。人们对发生在偶电子络合物中的有机金属反应了解甚多，偶电子络合物含有一个易于接近的电荷和氧化态的金属中心。该项目超越了这些研究领域，以了解涉及奇数电子，不常见金属氧化态或多个金属中心的情况下的反应细节。结果将增加对与化学制造有关的反应的理解

This award in the Inorganic, Bioinorganic, and Organometallic Chemistry Program provides continued support to work by Dr. Robert G. Bergman of the Chemistry Department, University of California at Berkeley, on reactions of organic molecules with transition metal complexes. One area of investigation is the synthesis of new complexes containing two metals located in close proximity to one another. Specifically targeted are systems that are unsymmetrical, due to either the presence of two metals with very different electronic properties or to the presence of different reactive ligands at each metal center. Research on these materials will focus on reactions that are applicable to the chemical utilization of small organic molecules, such as alkenes, alkynes and carbon dioxide, and to the type of transformations important in organic synthesis, such as carbon-carbon or carbon-heteroatom bond formation. A second area of investigation is the generation of organometallic species that are highly reactive due to the presence of an unpaired electron at the metal center, that is, organometallic free radicals, and capable of forming a relatively strong covalent bond to the metal. Also, methods for the abstraction of protons from relatively unacidic metal hydrides will be developed in order to generate very nucleophilic, low valent anionic metal complexes. Much is known about organometallic reactions that take place in even-electron complexes that contain a single metal center with easily accessible charges and oxidation states. This project moves beyond these areas of investigation to obtain understanding of reaction details in cases involving an odd-number of electrons, uncommon metal oxidation states, or more than one metal center. The results will increase understanding of reactions which are relevant to chemical manufacturing