Synthesis of Polycyclic Ethers via Alkynol Cycloisomerization

本研究的重点是发展过渡金属催化的烷基醇环化反应，得到异构内环烯醇醚。该方法代表了两种生物活性离子载体，鲁替诺霉素和钙霉素合成的关键步骤。该教育计划的重点是通过鼓励使用归纳推理技能来教授化学。通过这个职业奖，合成有机项目支持了西北大学化学系Frank E. McDonald博士的研究和教育计划。麦克唐纳教授的研究重点是开发合成聚醚天然产物的新方法，这些化合物具有重要的生物学特性。麦当劳处理器的教育计划的重点是通过鼓励使用归纳推理技能来教授化学。

The focus of this research is the development of the transition metal-catalyzed cyclization of alkynols to afford isomeric endocyclic enol ethers. The methodology represents a key step in the projected synthesis of two bioactive ionophores, routiennocin and calcimycin. The focus of the educational plan involves the teaching of chemistry by encouraging the use of inductive reasoning skills. With this CAREER award, the Synthetic Organic Program is supporting the research and educational plan of Dr. Frank E. McDonald of the Department of Chemistry at Northwestern University. Professor McDonald will focus his research efforts on the development of new methods for the synthesis of polyether natural products, compounds posessing important biological properties. The focus of Processor McDonald's educational plan involves the teaching of chemistry by encouraging the use of inductive reasoning skills.