Novel Degradable Polymers for Cellular Adhesion

这个项目是为了继续先前资助的NSF研究一种新的共聚物，聚乳酸-共赖氨酸PLAL，它是可生物降解的，它将被用作容纳哺乳动物细胞的基质，并可能最终用作人造器官。主要研究人员（pi）建议对这种聚合物进行修饰，以增加细胞附着位点的密度，开发可用于可注射移植系统的光聚合聚合物系统的方法，并对这两种类型的聚合物进行表征。＊＊＊

9525913 Langer This project is to continue previously funded NSF work on a new copolymer, poly (lactic acid-co-lysine) PLAL, which is biodegradable, which is to be used as a matrix to hold mammalian cells, and which may ultimately serve as an artificial organ. The Principal Investigators (PIs) propose to modify this polymer to increase the density of attachment sites for cells, to develop approaches to create photopolymerized polymer systems which could lead to injectable transplantation systems, and to characterize both of these types of polymers. ***