Synthetic Models of Flavoenzyme Activity

在有机动力学项目的资助下， 马萨诸塞大学阿默斯特分校将研究非共价键合 影响黄素酶氧化还原特性的因素。为此 主要研究者准备了人工绑定 这些地点模仿自然地点，但允许他量化 据信影响氧化还原性能的各个因素。的 认为重要的两个主要因素是氢键， π叠加初步证据表明，该项目将在 成功 了解酶过程的细节将为科学家提供 与知识，以修改范例和程序，以改善 治疗药物功效。这个项目从一个年轻的调查员，如果 成功，将提供所需的信息，如何黄素酶的功能。 由于这些酶是必需的生理部分，本研究 在健康相关领域具有巨大潜力。这些结果可能 可用于更广泛范围的氧化还原系统， 材料和电子器件。

With funding from the Organic Dynamics Program, Professor Rotello of the University of Massachusetts-Amherst will investigate non-covalent bonding factors that influence the redox properties of flavoenzymes. For this investigation the principal investigator has prepared artificial binding sites which mimic the natural sites, but allow him to quantify the individual factors that are believed to affect the redox properties. The two major factors which are considered important are hydrogen bonding and pi stacking. Preliminary evidence suggests that the project will be successful. Understanding the details of enzymatic processes will provide scientists with the knowledge to modify paradigms and procedures for improved therapeutic drug efficacy. This project from a young investigator, if successful, will provide needed information on how flavoenzymes function. Since these enzymes are essential physiological moieties, this research has significant potential in the health related domain. These results may be useful to a broader scope of redox systems that are germane to organic materials and electronic devices.