Multidisciplinary Collaborative: Behavioral and Biological Effects of Chronic Social Stress

IBN-9511349和9528213 C. 还有麦克尤恩，布鲁斯 社会压力是生活中常见且持久的特征，具有重要的行为和生理影响。 夏威夷大学行为神经生物学实验室和洛克菲勒大学神经内分泌学实验室之间的多学科研究合作旨在描述和分析这些影响。 以前的研究表明，单一的，两周的压力时期可以产生增加的防御行为和减少的社会和生殖行为;更高水平的压力激素和损害的机制，通常限制压力激素的行动;和大脑神经化学系统的广泛变化。 虽然这些变化开始提供对慢性社会压力的生理和行为反应动态的见解，但已完成的研究仅测量了该过程中的单个时间点。 该计划将调查与压力相关的行为和生理变化随着时间的推移的发展，并将确定在单一或多个时期的慢性社会压力后压力效应的持续性。 此外，个体差异将被视为对社会压力反应的决定因素。 因此，拟议的计划将利用这两个研究小组的不同方法和专业知识，提供一个独特的全面的描述和分析，在生态适当的情况下，社会压力的影响。

IBN-9511349 and 9528213 Blanchard, D. C. and McEwen, Bruce Social stress is a common and enduring feature of life with important behavioral and physiological effects. A multidisciplinary research collaboration between the Laboratory of Behavioral Neurobiology at the University of Hawaii and the Laboratory of Neuroendocrinology at Rockefeller University is aimed at description and analysis of these effects. Previous work indicates that single, two-week stress periods can produce increased defensive behavior and decreased social and reproductive behavior; higher levels of stress hormones and impairment of mechanisms that normally limit stress hormone action; and widespread changes in brain neurochemical systems. Although these changes are beginning to provide insights into the dynamics of the physiological and behavioral response to chronic social stress, completed studies have measured only a single time point in the process. The proposed program will investigate the development of stress-related behavioral and physiological changes over time, and will determine the persistence of stress effects following single or multiple periods of chronic social stress. In addition, individual differences will be examined as determinants of responsivity to social stress. The proposed program will thus draw upon the different approaches and expertise of these two research groups to provide a uniquely comprehensive description and analysis of the effects of social stress in an ecologically appropriate situation.