Biosynthesis of Secondary Metabolites from Blue-Green Algae

本研究的重点是生物合成的研究， 蓝藻毒素Anatoxin a-（s）n Anabaena flos-aquae NCR 525-17， 铜绿微囊藻PCC-7820中的微囊藻毒素-LR 念珠藻GSV 224中的念珠藻素-1， 地衣岩蕨ATCC 29204和真菌生物碱 须枝藻科 该项目的最终目标之一将是 在酶水平上研究生物合成过程。 还有几 非天然的C-取代的天冬氨酸和β-丙氨酸将被 作为念珠藻素“异常”生物合成的底物 类似物 有了这个更新奖，合成有机计划是 支持Richard E.摩尔和托马斯K.海姆沙伊特 他是马诺阿夏威夷大学化学系的教授。 Drs. 摩尔和赫姆沙伊特将把他们的工作重点放在生物合成研究 蓝绿藻产生的蓝藻毒素。 重要的是要 确切地了解如何有效的蓝藻毒素产生，因为 在富营养化的淡水和半咸水中有毒的蓝绿藻水华 湖泊带来了严重的环境和健康问题，不仅 生活在周围海岸的家养动物和野生动物， 依赖饮用水的人口。

The focus of this research is the biosynthetic study of the cyanobacterial toxins anatoxin a-(s)n Anabaena flos-aquae NCR 525-17, microcystin-LR in Microcystis aeruginosa PCC-7820, the cytotoxins cryptophycin-1 in Nostoc sp. GSV 224, cylindrocyclophane D in Cylindrospermum lichenforme ATCC 29204 and fungal alkaloids from the Stigonemataceae. One of the ultimate goals of the project will be to study biosynthetic processes at the enzymatic level. Also several unnatural C-substituted aspartic acids and beta-alanines will be evaluated as substrates for the `aberrant` biosynthesis of cryptophycin analogs. With this renewal award, the Synthetic Organic Program is supporting the research of Drs. Richard E. Moore and Thomas K. Hemscheidt of the Department of Chemistry at the University of Hawaii, Manoa. Drs. Moore and Hemscheidt will focus their work on biosynthetic studies of cyanobacterial toxins produced by blue-green algae. It is important to learn exactly how potent cyanobacterial toxins are produced , since poisonous blooms of blue-green algae in eutrophic freshwater and brackish lakes present serious environmental and health problems , not only to domestic animals and wildlife that live on the surrounding shores, but to human populations that depend on the water for drinking.