RIMI: RPG: Molecular and Biochemical Studies of Surface Proteins and Cell Signalling

提出了与巴尔通体芽孢杆菌受体和信号传导机制研究相关的计划活动。规划活动的具体目标包括：(1)对芽孢杆菌巴尔通体进行初步调查；(2)与胡佛博士（范德比尔特大学）和明尼克博士（蒙大拿大学）合作；(3)参加几次科学会议。本研究的具体目的是：(1)鉴定和表征宿主细胞表面的巴尔通体受体(2)确定蛋白质磷酸化是否在巴尔通体被宿主细胞摄取过程中起作用(3)确定巴尔通体外膜蛋白是否能刺激宿主靶细胞增殖。＊＊＊

9550643 Hill Planning activities related to the investigation of Bartonella bacilliformis receptors and signaling mechanisms are proposed. Specific aims of the planning activities include (1) performance of preliminary investigations on Bartonella bacilliformis (2) collaborations with Dr. Hoover (at Vanderbilt) and Dr. Minnick (at the University of Montana) and (3) attend several scientific meetings. The specific aims of the research are (1) identify and characterize the Bartonella receptor on host cell surfaces (2) determine whether protein phosphorylation has a role in the uptake of Bartonella into host cells (3) determine whether outer membrane proteins of Bartonella can stimulate host target cells to proliferate. ***