Collision and Surface-Induced Dissociation of Singly and Multiply Charged Ions

离子-分子相互作用的详细反应动力学形成了本项目的研究重点，由分析和表面化学计划支持。Futrell教授和他在特拉华大学的同事利用交叉分子束方法来探测与分析质谱中离子激活相关的碰撞诱导解离过程。这种独特的方法提供了有关能量分配、碎片机制和能量释放的信息，从而提高了对质谱碎片模式的基本理解。这种方法正被扩展到高分子量，由电喷雾电离产生的多重带电离子，以及离子表面相互作用和表面诱导解离过程的研究。串联质谱方法的使用提供了许多关于生物重要化合物的结构信息，特别是随着低能量电离方法（如电喷雾）的出现。使用离子惰性气体或离子表面碰撞来激活分析离子，大大增加了这些方法的能力。该项目的研究旨在发展这些活化过程的详细机制理解，提高其在分析质谱法中的适用性。

The detailed reaction dynamics of ion-molecule interactions forms the focus of the research of this project supported by the Analytical and Surface Chemistry Program. Professor Futrell and his coworkers at the University of Delaware utilize crossed molecular beam methods to probe the collision induced dissociation processes relevant to ion activation in analytical mass spectrometry. This unique approach provides information about energy partitioning, fragmentation mechanisms, and energy release which improves the fundamental understanding of mass spectrometric fragmentation patterns. This approach is being extended to high molecular weight, multiply charged ions produced by electrospray ionization, and to the investigation of ion-surface interactions and the process of surface induced dissociation. The use of tandem mass spectrometric methods has provided much structural information about biologically significant compounds, especially with the advent of low energy ionization methods such as electrospray. The use of ion-noble gas or ion-surface collisions to activate the analyte ion has added significantly to the power of these methods. The research of this project is directed to developing the detailed mechanistic understanding of these activation processes, improving their applicability for analytical mass spectrometry.