The Tandem Aldol-Tishchenko Reaction: New Methodology for Stereoselective Synthesis

本研究的重点是发展空间位阻测量的新方法 控制碳-碳键的形成。 使用的反应， 锂烯醇化物与过量醛反应，得到反式1，3-二醇衍生物 通过一系列的添加，然后是分子内的Tishchenko型 将探索脱附-转移反应。 范围、机制和 将该方法应用于有机合成问题， 压力很大有了这个新奖项，合成有机计划是 支持基思A.沃佩尔是一名年轻的调查员， 加州大学欧文分校化学系。 Woerpel教授将把工作重点放在开发方法上， 立体控制的碳-碳键形成。 方法，其中 使用一系列的加成和还原反应，将提供新的 合成生物活性分子的途径。

The focus of this research is to develop new methods for sterically controlled carbon-carbon bond formation. The use of the reaction of lithium enolates with excess aldehyde to afford anti 1,3-diol derivatives via a sequence of addition followed by an intramolecular Tishchenko-type hydride-transfer reaction will be explored. The scope, mechanism and application of the methodology to organic synthetic problems will be stressed. With this new award, the Synthetic Organic Program is supporting the research of Dr. Keith A. Woerpel, a young investigator in the Department of Chemistry at the University of California, Irvine. Professor Woerpel will focus his work on developing methods for stereocontrolled carbon-carbon bond formation . The methodology, which uses a sequence of addition and reduction reactions, will offer new pathways for the syntheses of biologically active molecules.