Quinones, Radicals and Redox-Active Amino Acids, Gordon Research Conference to be held on May 4th-9th at II Ciocco, Pisa, Italy

在此支持下，“醌、自由基和氧化还原活性氨基酸”的戈登研究会议将于5月4日至9日在意大利Ciocco举行。这将是关于这一主题的第四次国际会议，会议将强调在氨基酸残基翻译后修饰过程中自由基和醌类衍生物的最新研究进展，这些修饰是由几类酶，如氧化酶、脱氢酶、还原酶、加氧酶、焦氧化酶和参与分子重排的酶，如丙酮酸甲酸裂解酶和赖氨酸2,3-氨基交换酶产生的。这些自由基和醌类作为高活性的辅助因子，影响诸如C-H键裂解之类的难催化。这些酶中自由基的控制使用与自由基的不受控制的产生形成对比，自由基会损害生物材料。这笔资助将部分用于支付参加会议的科学家的旅费，并适当优先考虑年轻科学家和代表性不足的群体。***细胞中产生的不受控制的自由基会引起损伤，但某些酶对自由基的控制可以产生有用的分子。由几种酶产生的醌和自由基可以作为辅助因子，有效地切断化学键，否则就很难断裂。对这些酶的研究已经引起了越来越多科学家的关注，第四届关于这一主题的国际会议将于5月4日至9日在意大利比萨的Ciocco举行。会议将由麻省理工学院的乔安妮·斯图比教授组织；来自美国的15位发言者将加入由来自英国、意大利、日本、荷兰、瑞典和其他地方的发言者组成的论坛。青年科学家和代表性不足的群体将获得该资助，与来自美国和国外的科学家一起参加本次会议。

9618564 Stubbe A Gordon Research Conference on "Quinones, Radicals and Redox-Active Amino Acids", will be held May 4th to 9th at Il Ciocco, Italy, under the auspices of this support. This will be the fourth international conference on the subject and will emphasize recent advances in the study of radical and quinone derivatives generated during post-translational modification of amino acid residues by several classes of enzymes such as oxidases, dehydrogenases, reductases, oxygenases, pyroxidases and those involved in molecular rearrangements like pyruvate formate lyase and lysine 2,3-aminomutase. These radicals and quinones act as highly reactive cofactors for effecting difficult catalysis such as C-H bond cleavages. The controlled use of radicals in such enzymes contrasts with the uncontrolled production of radicals which damage biological material. The support is to be used to partially cover travel expenses of scientists attending the meeting, with due priority given to young scientists and under-represented groups. *** Uncontrolled radicals produced in a cell elicit damage, but controlled use of radicals by certain enzymes can produce useful molecules. Quinones and radicals produced by several classes of enzymes can act as cofactors in effective cleavage of chemical bonds that are otherwise difficult to break. Studies on these enzymes have attracted attention of increasing number of scientists, and a fourth international conference on this subject will be held May 4th to 9th at Il Ciocco, Pisa, Italy. The conference will organized by Professor Joanne Stubbe, M. I.T.; fifteen speakers from USA will join a forum of others from England, Italy, Japan, Netherland, Sweden, and elsewhere. Young scientists and under-represented groups will be subsidized by this support to participate in this conference, along with scientists from USA and abroad.