Intramolecular Anodic Olefin Coupling Reactions

本研究的重点是发展应用于活性自由基中间体的电化学方法学。基于阳极电化学的自由基阳离子环化反应将被用于制备复杂的有机分子。感兴趣的目标将是灯盏花素B、滨藜芦酸B、蒜素A和3-取代的脯氨酸衍生物。这项研究旨在展示电化学合成在解决复杂合成问题中的普遍用途。通过这一奖项，合成有机项目支持了华盛顿大学化学系的凯文·D·默勒博士的研究。默勒教授将把工作重点放在利用电化学合成复杂的有机分子上。感兴趣的目标分子具有重要的生物学特性。

The focus of this research is the development of electrochemical methodology for the application of reactive radical intermediates. Radical cation based cyclization reactions based on anodic electrochemistry will be used to elaborate complex organic molecules. The targets of interest will be crinipellin B, scopadulcic acid B, alliacol A and 3-substituted proline derivatives. The research is designed to show the general utility of electrochemical synthesis for solving complex synthetic problems. With this award, the Synthetic Organic Program is supporting the research of Dr. Kevin D. Moeller of the Department of Chemistry at Washington University. Professor Moeller will focus his work on using electrochemistry for the synthesis of complex organic molecules. The target molecules of interest have important biological properties.