Quasi-Equivalence: Motion and Adaptability in Living Molecules Conference being held second week of January 1997 in Tallahassee, Florida

9631049 Makowski该基金申请资助一次会议，以探索我们对大分子组装体的结构和活性的理解的基本原理。 会议将于1997年1月的第二个星期在佛罗里达的塔拉哈西举行。 将有两个完整的科学会议与约25名发言者的谈话。 预计将有100-150名科学家参加。 1962年，卡斯帕和克鲁格引入了准等价的概念来解释二十面体病毒颗粒表面蛋白质的排列。 在过去的30年里，这个概念在塑造我们对病毒和其他大分子组装的研究和理解方面发挥了重要作用。 在这30年中，我们获得的关于蛋白质的信息量爆炸式增长，基于电子显微镜研究的原始概念已经得到改进，以考虑到晶体病毒结构和其他蛋白质-蛋白质相互作用的显着结果。 尽管如此，它仍然是我们如何看待大分子组装的哲学基础。 通过组织这次会议，我们试图将参与这一概念发展的个人聚集在一起，以及那些在过去30年中产生关于大分子组装和病毒的高分辨率信息的人。 大多数主要发言人已经同意不参加这次会议。 这可能是我们最后的机会之一，我们必须把这些概念的创始人与许多为它的发展做出贡献的科学家聚集在一起。 这是一个总结我们对大分子组装的理解的基础原则的机会，并定义我们需要继续询问的关于大分子运动和适应性的问题。 %%%

9631049 Makowski This grant requests funding for a conference to explore the principles underlying our understanding of the structure and activity of macromolecular assemblies. The conference will take place in the second week of January, 1997, in Tallahassee, Florida. There will be two full days of scientific sessions with talks from approximately 25 speakers. We expect an attendance of 100-150 scientists. In 1962, Caspar and Klug introduced the concept of quasi-equivalence to explain the arrangement of proteins on the surface of icosahedral virus particles. The concept has played an important part in shaping our study and understanding of viruses and other macromolecular assemblies for the past 30 years. In those 30 years the amount of information that we have obtained about proteins has exploded, and the original concept, based on electron microscope studies, has been refined to take into account the remarkable results on the structure of crystalline viruses and other protein-protein interactions. Nevertheless, it survives as a philosophical basis for much of how we think about macromolecular assemblies. By organizing this conference, we seek to bring together the individuals who were involved in the development of the concept from its origins, and those who have generated high resolution information about macromolecular assemblies and viruses over the past 30 years. Most of the principal speakers have already agreed t participate in this conference. This may be one of the last chances we have to bring together the originators of the concepts with so many scientists who have contributed to its development. It is an opportunity to summarize the principles underlying our understanding of macromolecular assemblies, and to define the questions we need to continue asking about the movement and adaptability of macromolecules. %%%