Sex-specific epigenetic atlas across lifespan

该项目旨在揭示性别特异性分子标记，这些标记可以预测或介导人类多种组织的健康衰老。该项目有望产生细胞异质性和表观遗传控制的表型和健康衰老的新知识。此外，我们期望揭示男性和女性之间不同的年龄相关变化，这是一个代表性的慢性研究领域。这些结果将导致对整个生命周期的基本生物过程的全面理解，我们开发的开放获取地图集将支持基于证据的个性化健康策略，使澳大利亚人更健康。

This project aims to uncover sex-specific molecular marks that either predict or mediate healthy ageing across multiple tissues in humans. This project expects to generate new knowledge of cellular heterogeneity and epigenetic control of phenotype and healthy ageing. Further, we anticipate to uncover age-associated changes that differ between males and females, an area of chronic research under representation. These outcomes will lead to a comprehensive understanding of fundamental biological processes across lifespan, and our development of an open access atlas will underpin evidence-based personalised health strategies to keep Australians healthier for longer.