Conference: Modeling in Biochemical Engineering, October 11 - 12, 1996

9634351 Srienc本次会议的目的是汇聚一批来自美国和欧洲的生化工程师和生物学家，深入讨论数学建模在生化工程领域所发挥的作用，以及未来如何加强其对生物技术的贡献。这次会议将有四个技术会议，包括：91)生物和非生物阶段的表征，(2)细胞群体的红细胞模型，(3)代谢模型，和(4)复杂细胞系统的模型。第一次会议将讨论用来描述生物阶段的不同变量：(A)生物阶段的实验测量及其是否适合描述细胞的生理状态，以及(B)非生物阶段的实验测量是否适合描述细胞在生物阶段的生理状态的变化速度。第二届会议将提出与说明不同细胞(或小体)之间生物量分离的细胞模型或统计种群平衡模型有关的问题。第三届会议将涉及一类非红细胞模型，即将生物量视为结构化实体的代谢模型。这些模型解释了代谢途径的内部调节。本次会议将讨论代谢工程应用中的问题。第四场会议将致力于对复杂生物体和超细胞系统之间的关联问题进行建模。

9634351 Srienc The objective of this conference is to bring together a select group of biochemical engineers and biologists from the United States and Europe to discuss in depth the role mathematical modeling is playing in the area of biochemical engineering and how its contributions to biotechnology can be enhanced in the future. This conference will have four technical sessions which include: 91) Characterization of biotic and abiotic phases, (2) Corpuscular models of cell populations, (3) metabolic models, and (4) modeling of complex cellular systems. The first session will scope the different variables used to characterize: (a) the biotic phase with regard to their experimental measurement as well as their suitability to describe the physiological state of the cell, and (b) the abiotic phase with regard to their experimental measurement as well as their suitability to describe the rate of change of physiological state of cells in the biotic phase. The second session will raise issues related to corpuscular models or statistical population balance models which account for the segregation of biomass among distinct cells (or corpuscles). The third session will involve a class of non- corpuscular models, i.e. metabolic models, which view biomass as a structured entity. These models account for internal regulation of metabolic pathways. This session will address problems in the application of metabolic engineering. The fourth session will be devoted to modeling issues connected complex organisms and supracellular systems.