Investigations of the Use of Pentacovalent Organophosphorus Compounds in the Production of Phosphonates

本研究的重点是开发合成方法， 五价氧杂磷杂环戊二烯（P（V））与各种 用于生产高度取代的膦酸酯的亲电试剂。 的 方法学将被应用于合成的膦酸酯类似物的 生物活性有机磷 P（V）与 不同配体对磷的影响及缩合反应的机理 P（V）和亲电体之间的关系也将被探讨。 与此 更新奖，合成有机计划和办公室 多学科活动正在支持辛西娅博士的研究 K.蒙大拿州立大学化学系的麦克卢尔说。 麦克卢尔教授将把她的工作重点放在开发方法， 含有生物学意义的膦酸酯化合物的制备方法 抗代谢物和酶活性探针。 这种类型的化合物可以 具有作为抗病毒药、抗生素、抗酸中毒剂和 可以表现出除草和杀虫活性。

The focus of this research is to develop synthetic methodology using the condensations of pentacovalent oxaphospholenes (P(V)'s) with various electrophiles for the production of highly substituted phosphonates. The methodology will be be applied to the synthesis of phosphonate analogs of biologically active organophosphates. The reactivities of P(V)'s with differing ligand on phosphorus and the mechanism(s) of the condensations between P(V)'s and electrophiles will also be explored. With this renewal award, the Synthetic Organic Program and the Office of Mutlidisciplinary Activities are supporting the research of Dr. Cynthia K. McClure of the Department of Chemistry at Montana State University. Professor McClure will focus her work on developing methods for the preparation of phosphonate containing compounds of biological interest as antimetabolites and enzyme active probes. Compounds of this type could have medicinal value as antivirals, antibiotics, antiacidosis agents and could exhibit herbicidal and insecticidal activity.