Engineering pressurized liquid droplets to generate high-efficiency aerosols for targeted respiratory delivery

加压计量吸入器(PMDI)用于呼吸系统疾病的许多宏观方面已被认识，但尚未在基础水平上被理解并相应地加以利用。特别是，非水PMDI中的液滴电荷机制仍然难以捉摸。目前，尽管市面上有多种药物可以作为经皮计量吸入器获得，但这些系统的效率很低，大多数设备向肺部输送的药物不到20%。对这些系统的洞察对于成功提高工业中气雾剂制剂的性能，最终转化为卓越的患者治疗至关重要。该项目将创建可应用于开发新一代吸入性药物的pMDI配方的理论模型。

Many macroscopic aspects of pressurised Metered Dose Inhaler (pMDI) for respiratory diseases are recognised, but are yet to be understood at the basic level and accordingly exploited. In particular, the droplet charge mechanism in non-aqueous pMDIs remains elusive. Currently, although a wide range of drugs are commercially available as pMDIs, the efficiency of these systems is poor, with most devices delivering less than 20 per cent to the lung. An insight into these systems is crucial to successfully enhance the performance of aerosol formulations in industry, ultimately translating into superior patient therapy. This project will create a theoretical model for pMDI formulation that can be applied to the development of a new generation of inhalation medicines.