Upgrade of NMR Instrumentation in a College Wide Facility

化学研究仪器和设施(CRIF)计划、主要研究仪器(MRI)计划和多学科活动办公室(OMA)颁发的这一奖项将帮助加州大学河滨分校化学系升级300 MHz和500 MHz核磁共振光谱仪。该设备将加强以下领域的研究：(1)天然产物的全合成，(2)污染物在多孔介质中传输的核磁共振表征，(3)胰岛素六聚体中具有较大氢化学位移的氢键质子所起的结构-功能，(4)构象分析及其与生物活性的关系，(5)肽和蛋白质中侧链交联的立体化学，以及(6)具有重要生物医学意义的天然产品的合成、结构和生物学研究。核磁共振波谱是化学家用来解释分子结构的最有力的工具。它被用来识别未知物质，表征分子内原子的特定排列，并研究溶液中分子之间相互作用的动力学。对于正在进行前沿研究的化学家来说，获得最先进的核磁共振光谱是必不可少的。这些核磁共振研究的结果在聚合物、催化和生物学等领域都是有用的。

This award from the Chemistry Research Instrumentation and Facilities (CRIF) Program and the Major Research Instrumentation (MRI) Program and the Office of Multidisciplinary Activities (OMA) will assist the Department of Chemistry at University of California @ Riverside to upgrade a 300 MHz and a 500 MHz NMR Spectrometer. This equipment will enhance research in a number of areas including the following: (1) total synthesis of natural products, (2) NMR characterization of pollutant transport through porous media, (3) structure-function played by H-bonded protons with large H-chemical shifts in the insulin hexamer, (4) conformation analysis and the relationship to biological activity, (5) stereochemistry of side chain crosslinking in peptides and proteins, and (6) synthesis, structural and biological studies of biomedically significant natural products. Nuclear Magnetic Resonance (NMR) spectroscopy is the most powerful tool available to chemists for the elucidation of the structure of molecules. It is used to identify unknown substances, characterize specific arrangements of atoms within molecules, and to study the dynamics of interactions between molecules in solution. Access to state-of-the-art NMR spectrometry is essential to chemists who are carrying out frontier research. The results from these NMR studies are useful in the areas such as polymers, catalysis, and in biology.