Expanded Porphyrins and Calixpyrroles

德克萨斯大学奥斯汀分校化学和生物化学系的乔纳森·L·塞斯勒教授因其对扩展的卟啉和杯并吡咯的研究而得到有机和高分子化学计划的支持。通过合成扩展的卟啉系统，包括那些旨在提供三维配位几何结构的系统，以补充更简单的卟啉衍生物提供的平面到近平面几何结构，Sessler教授评估了这些系统对阴离子络合、阳离子配位和中性底物结合的几何要求。相关研究涉及两个新的底物结合平台，杯(N)吡咯和杯(N)吡啶的基本分子识别性能。离子或分子与受体之间的特定相互作用是无数生化过程中的一个重要特征。虽然正电物种(阳离子)的“分子识别”受到了严格的审查，但对负电分子(阴离子)的识别发展得更慢。在有机化学和高分子化学计划的支持下，德克萨斯大学奥斯汀分校化学和生物化学系的乔纳森·L·塞斯勒教授准备了旨在显示与各种阴离子特定相互作用的大环环状化合物。由于它们独特的结构特征，其中许多化合物还可以作为阳离子和中性分子的结合剂。通过这些化合物的合成和研究，塞斯勒教授获得了有关离子和分子结合中结构和功能之间关系的关键信息。

Professor Jonathon L. Sessler, of the Department of Chemistry and Biochemistry at the University of Texas at Austin, is supported by the Organic and Macromolecular Chemistry Program for his studies of expanded porphyrins and calixpyrroles. Through the synthesis of expanded porphyrin systems, including those designed to provide three-dimensional coordination geometries to complement the planar to near-planar geometry afforded by simpler porphyrin derivatives, Professor Sessler assesses the geometric requirements of anion complexation, cation coordination, and neutral substrate binding by these systems. Related studies address the basic molecular recognition properties of two new substrate binding platforms, the calix(n(pyrroles and calix(n)pyridines. The specific interaction between ions or molecules and receptors for them represents a critical feature in countless biochemical processes. Whereas the `molecular recognition` of positively charged species (cations) has received intense scrutiny, the recognition of negatively charged molecules (anions) has developed more slowly. With the support of the Organic and Macromolecular Chemistry Program, Professor Jonathon L. Sessler, of the Department of Chemistry and Biochemistry at the University of Texas at Austin, prepares large-ring cyclic compounds designed to display specific interactions with various anions. Given their unique structural features, many of these compounds also act as binding agents for cations and neutral molecules. Through the synthesis and study of these compounds, Professor Sessler gains critical information regarding the relationship between structure and function in the binding of ions and molecules.