U.S.-Argentina Cooperative Research: Studies on the Mechanism of Action of Aldosterone in Brain

9802428 McEwen美洲项目奖将资助洛克菲勒大学Bruce McEwen博士和阿根廷布宜诺斯艾利斯生物医学实验研究所Alejandro F. de Nicola博士为期两年的合作研究项目，研究盐食欲的调节和控制。盐的食欲与一种重要的体内平衡、动机行为有关，是研究食欲和食欲行为的一个模型。这些研究将为动机状态和行为的神经基础提供见解。利用分子生物学和经典生理学方法相结合的最新技术，合作者将重点研究杏仁核作为矿物皮质激素诱导盐食欲的重要靶点区域。原位杂交组织化学将用于进一步研究肾上腺类固醇受体的作用。该项目将解决关于大脑在调节液体代谢方面的基本功能的重要问题。此次合作将结合美国方面在神经科学和分子生物学方面的专业知识，以及阿根廷方面在生理学、药理学和神经内分泌学方面的专业知识。＊＊＊

9802428 McEwen This Americas Program award will fund a two-year cooperative research project between Dr. Bruce McEwen, Rockefeller University, and Dr. Alejandro F. de Nicola, Instituto de Biologia y Medicina Experimental, Buenos Aires, Argentina, on regulation and control of salt appetite. Salt appetite is associated with an important homeostatic, motivated behavior, and serves as a model for studying appetites and appetitive behaviors. These studies will provide insights into the neural basis of motivational states and behavior. Using state of the art techniques linking molecular biology and classical physiological approaches, the colaborators will focus on the amygdala as an important target area for mineralocorticoid induction of salt appetite. In situ hybridization histochemistry will be utilized to further investigate the role of adrenal steroid receptors. The project will address important, unanswered questions on the fundamental function of the brain in the regulation of fluid metabolism. This collaboration will combine the expertise of the US side in neurosciences and molecular biology, with the expertise of the Argentinean side in in physiology, pharmacology and neuroendocrinology. ***