Programme coordination and instruments to achieve the structural goals of the priority programme

设立DFG优先项目的目的是：􀂾建立网络并协调德国领先的肥大细胞实验室和中心的工作􀂾成功地领导了德国的肥大细胞研究，从小鼠模型的发现过渡到更好的治疗方案。它还将在国际上加强德国科学家在这一研究领域的地位􀂾指导和简化实验室之间的相互作用，这些实验室能够确定肥大细胞激活的相关途径和疾病模型中的作用，而不同专业的临床科学家能够将这些发现转化为条件，从而可以测试针对这些途径在预防或控制诸如细菌和其他感染等疾病方面的安全性和有效性。过敏和自身免疫性疾病、毒液和其他毒素引起的病症以及肿瘤􀂾为招募和培训优秀的初级科学家提供了条件，以确保德国科学在这一新兴研究领域的强大地位。该计划的一个特别重点是促进和促进目前在国外工作的该领域领先的德国科学家回国（人才获取）􀂾发起和促进积极和持续的合作努力以及与国际肥大细胞网络(如EMBRN，欧洲肥大细胞和嗜碱性粒细胞网络)和肥大细胞驱动疾病联盟（例如EU COST ACTION BM1007“肥大细胞和嗜碱性粒细胞”）􀂾启动并建立一个与生物技术和大型制药合作伙伴交流和互动的平台。该申请描述了优先计划内正在进行和预期的结构性努力和行动，并要求进一步资助其协调和实施。

This DFG priority programme was set up to: 􀂾 establish a network and coordinate the efforts of leading mast cell laboratories and centers in Germany 􀂾 successfully lead mast cell research in Germany through the transition from findings in mouse models to better treatment options for patients. It will also internationally strengthen the position of German scientists in this field of research 􀂾 guide and streamline the interactions between labs that can identify relevant pathways of mast cell activation and effects in models of disease and clinical scientists of various specialties who can transfer these findings to conditions in which targeting these pathways can be tested for their safety and efficacy in preventing or controlling diseases such as bacterial and other infections, allergic and autoimmune diseases, conditions caused by venoms and other toxins, and tumors 􀂾 provide for the recruitment and training of excellent junior scientists to secure a strong position of German science in this emerging field of research. A special focus of this programme is also to promote and facilitate the return of leading German scientists in this field who are presently working abroad (brain gain) 􀂾 launch and promote active and continued collaborative efforts and productive interactions with international mast cell networks (such as EMBRN, the European Mast Cell and Basophil Network) and consortia for mast cell-driven diseases (e.g. the EU COST ACTION BM1007 “Mast Cells and Basophils”) 􀂾 start and build up a platform for the exchange and interaction with biotechs and big pharma partners This application describes ongoing and anticipated structural efforts and actions within the priority programme and asks for further funding of their coordination and implementation.