NSF/Alfred P. Sloan Foundation Postdoctoral Research Fellowship in Molecular Evolution for FY 1998

此行动资助了1998年美国国家科学基金会/Alfred P. Sloan分子进化博士后研究奖学金。这些奖学金支持涉及生物进化变化和适应框架内分子水平生物模式和过程的理论、比较、计算和/或实验分析的研究。这些研究还包括利用分子数据来解决更广泛的进化问题。每个奖学金支持在赞助实验室进行的研究和培训计划。这项研究和培训计划的题目是细菌病原体的适应性分子进化。13个可变重复序列（微卫星）嵌入在嗜血杆菌的毒力因子中。流感嗜血杆菌。这项研究验证了这样一个假设，即这些重复序列的遗传变异是决定这种细菌个体分离株进化成功的一个重要因素。正在对120种流行病学上不同的流感嗜血杆菌菌株进行基因分型，并确定突变率。

Abstract DBI-9803938 Dawn Field This action funds an NSF/Alfred P. Sloan Postdoctoral Research Fellowship in Molecular Evolution for 1998. These fellowships support studies involving the theoretical, comparative, computational, and/or experimental analyses of biological patterns and processes at the molecular level within the framework of organismic evolutionary change and adaptation. These studies also include the use of molecular data to address broader evolutionary questions. Each fellowship supports a research and training plan to be carried out in a sponsoring laboratory. The research and training plan for this fellowship is entitled adaptive molecular evolution of a bacterial pathogen. Thirteen mutable repeats (microsatellites) are embedded within virulence factors in Haemophilus. influenzae. This study tests the hypothesis that genetic variability at these repeats is an important factor in determining the evolutionary success of individual isolates of this bacterium. One hundred twenty epidemiologically diverse strains of H. influenzae are being genotyped, and rates of mutation determined.