Role of ubiquitin in retrovirus budding

病毒粒子。对这一建议的主要争论集中在泛素和泛素修饰酶（裂解酶和水解酶）在逆转录病毒出芽中的作用。在此基础上，我们将继续我们以前在这一领域的研究，我们与其他人一起证明，泛素-蛋白酶体系统（UPS）的上游因子，26 S蛋白酶体，是HIV-1和其他一些逆转录病毒有效出芽所必需的。我们的工作将有助于对病毒出芽的基本认识。此外，它还可能导致UPS的特定成分作为新型抗逆转录病毒治疗的潜在靶点的验证。

ing virions. The major ephasis on this proposal is focused on the role of Ubiquitin and Ubiquitin modifying enzymes (lyases and hydrolases) in retrovirus budding. With this we will continue our previous studies in this field where we together with others demonstrated, that an upsteam factor of ther Ubiquitin-proteasome system (UPS), the 26S proteasome, is required for efficient budding of HIV-1 and some other retroviruses. Our work will contribute to the basic understanding of virus budding. Further it might also lead to the validation of specific components of UPS as potential targets for novel antiretroviral therapy.