CAREER: Orthopaedic Biomechanics Research and Education

9875838van der meulen这份职业发展提案为康奈尔大学骨科生物力学制定了一个综合四年计划。本研究提出了三个具体目标：(1)通过小梁骨适应实验的分析模型来了解体内机械载荷与骨骼功能适应之间的关系；(2)将生物力学工程纳入机械工程课程；(3)向大学预科学生，特别是女生介绍机械和生物力学工程。骨负荷和骨功能适应之间的关系将在特殊外科医院进行的小梁骨适应实验的分析模型中进行检验。设计了一种装置，用于对兔股骨远端小梁施加已知的压缩力。加载区域的三维微计算机断层扫描将转换为大尺度有限元模型。这些小梁形态模型将用于理解施加载荷和小梁骨适应之间的相互作用。本提案将：(1)发展实验适应的三维模拟，这将涉及微观结构水平的实验和分析；(2)确定实验的体内负荷；(3)测量并纳入实验参数；(4)开发下一代材料模型，该模型比当前的均匀、各向同性方法更精确。这项工作的目标是提高模拟和解释体内适应实验的能力，最终导致模拟和预测未来实验的能力。该结果将对骨质疏松症等骨骼病理的理解产生影响。作为教育计划的一部分，生物力学工程案例研究和项目将被整合到本科设计课程中。这些项目的基础将与提议的研究相似：实验和分析方法的整合。此外，有趣、现实的跨学科项目将为学生提供基于问题和合作学习的经验，并有助于培养工程技能，以确保未来的成功。骨功能适应也将纳入课程。此外，一个综合案例为基础的研究生课程正在实施的第一年的学生生物力学。最后，研讨会和外展计划将向大学预科学生介绍机械和生物力学工程。动手生物力学和机械解剖研讨会将向大学预科学生介绍力学基础知识。重点将放在发展向女孩传授工程学的管道项目上。

9875838van der MeulenThis Career Development proposal develops an integrated four-year plan for Orthopaedic Biomechanics at Cornell University. The proposal develops three specific objectives: (1) to understand the relationship between in vivo mechanical loading and skeletal functional adaptation from analytical models of trabecular bone adaptation experiments; (2) to integrate biomechanical engineering into the mechanical engineering curriculum; and, (3) to introduce mechanical and biomechanical engineering to precollege students, particularly women.The relationship between skeletal loading and bone functional adaptation will be examined in analytical models of trabecular bone adaptation experiments being performed at the Hospital for Special Surgery. A device has been designed to apply a known compressive force to the trabecular bone of the rabbit distal femur. Three-dimensional micro-computed tomography scans of the loaded region will be converted into large-scale finite element models. These models of trabecular morphology will be used to understand the interaction between applied loading and trabecular bone adaptation. This proposal will: (1) develop three-dimensional simulations of experimental adaptation which will relate experiments and analyses at the microstructural level; (2) determine in vivo loading for the experiments; (3) measure and incorporate experimental parameters; and, (4) develop next generation material models which are more precise than the current uniform, isotropic approach. The goal of this work is to improve the ability to model and interpret in vivo adaptation experiments, leading ultimately to the ability to simulate and predict future experiments. The outcome will have implications for the understanding of skeletal pathologies such as osteoporosis. As part of the education plan, biomechanical engineering case studies and projects will be integrated into the undergraduate design curriculum. The foundation of these projects will be similar to the proposed research: integration of experimental and analytical methodology. The addition of interesting, realistic interdisciplinary projects will provide students experience with problem-based and cooperative learning and will help develop engineering skills to ensure future success. Bone functional adaptation will also be incorporated into the curriculum. In addition, an integrated case-based graduate curriculum is being implemented for first year biomechanics students.Finally, workshops and outreach programs will introduce precollege students to mechanical and biomechanical engineering. Hands-on biomechanics and mechanical dissection workshops will introduce precollege students to mechanics fundamentals. The focus will be on developing pipeline programs to present engineering to girls.