FASEB Summer Research Conference: Genetic Recombination and Chromosomes Rearrangements: Snowmass, CO, August 7-12, 1999

1999年FASEB基因重组和基因组重排夏季研究会议将于1999年8月7日至12日在科罗拉多州斯诺马斯举行。该计划包括八个全体会议，演讲者是同源，位点特异性和非同源重组的生物化学，分子和遗传学研究的前沿。同源重组是一种重要的DNA修复机制，也是减数分裂中同源染色体正确分离的必要条件。位点特异性重组是大多数程序性基因组重排的基础机制，因此在控制基因表达方面具有重要意义。最后，非同源重组也是一种重要的DNA修复机制（非同源末端连接），是大多数转座发生的机制。全体会议的主要议题将是：重组机制、真核重组、重组与DNA复制、重组与DNA修复、位点特异性重组、基因组重排、减数分裂过程和重组结构。在原核生物和真核生物中操作的重组系统都包括在该计划中，重点将放在知识迅速发展和方法可以广泛利用的领域。除全体会议外，还将通过海报会议和特设讲习班促进非正式互动。这个特别的会议在重组领域占据了一个独特的利基，因为它专门关注重组，并富有成效地汇集了该领域内代表的各种经验和见解。NSF基金将用于支持学生的旅行和参加会议。

The 1999 FASEB Summer Research Conference on Genetic Recombination and Genome Rearrangements will be held August 7-12, 1999, in Snowmass, Colorado. The program includes eight plenary sessions featuring speakers who are at the forefront of biochemical, molecular and genetic studies of homologous, site-specific and nonhomologous recombination. Homologous recombination is an important DNA repair mechanism and also is generally essential for the proper segregation of homologous chromosomes in meiosis. Site-specific recombination is the mechanism underlying most programmed genome rearrangements and thus is important in controlling gene expression. Finally, nonhomologous recombination also constitutes an important DNA repair mechanism (nonhomologous end joining) and is the mechanism whereby most transposition occurs. The major topics of the plenary sessions will be: recombination mechanisms, eukaryotic recombination, recombination and DNA replication, recombination and DNA repair, site-specific recombination, genome rearrangements, meiotic processes, and recombination structures. Recombination systems operating in both prokaryotes and eukaryotes are included in the program, and emphasis will be placed on areas where knowledge is rapidly developing and where methodologies can be widely exploited. In addition to the plenary sessions, informal interactions will be fostered through poster sessions and ad hoc workshops. This particular conference occupies a unique niche within the recombination field in that it focuses exclusively on recombination and productively brings together the diverse experiences and insights represented within the field. NSF funds will be used to support student travel and participation in the meeting.